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Comment
. 2015 Nov 3;112(44):13430-1.
doi: 10.1073/pnas.1518486112. Epub 2015 Oct 14.

Structural revelations of the human proton channel

Thomas E DeCoursey  1
Affiliations
Comment

Structural revelations of the human proton channel

Thomas E DeCoursey. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
The “three-click” model (Left) is a logical extrapolation to HV1 of S4 movement during K+ or Na+ channel opening. The three Arg (R) in the S4 helix all move outward past the yellow hydrophobic gasket, from intracellular to extracellular aqueous vestibules. In the new “one-click” model (Right), Li et al. (3) propose that S4 moves only one turn of the helix upwards.
Fig. 2.
Fig. 2.
The hydrophobic gasket (three yellow amino acids) is aligned in the new hHV1 model based on the CiVSP crystal structure (Left), but not in the chimeric mHV1 crystal structure (Right). In each closed channel viewed from the side, the three S4 Arg are blue and the Asp in S1 that produces proton selectivity is red. The apparent misalignment in mHV1 could reflect a disturbance due to the spliced-in S2–S3 segment from CiVSP, which ends two positions below V174, the anomalous residue in mHV1. Alternatively, a different amino acid might complete the gasket in mHV1.
See this image and copyright information in PMC

Comment on

References

    1. DeCoursey TE. The voltage-gated proton channel: A riddle, wrapped in a mystery, inside an enigma. Biochemistry. 2015;54(21):3250–3268. - PMC - PubMed
    1. DeCoursey TE. Voltage-gated proton channels: Molecular biology, physiology, and pathophysiology of the HV family. Physiol Rev. 2013;93(2):599–652. - PMC - PubMed
    1. Li Q, et al. Resting state of the human proton channel dimer in a lipid bilayer. Proc Natl Acad Sci USA. 2015;112:E5926–E5935. - PMC - PubMed
    1. Li Q, et al. Structural mechanism of voltage-dependent gating in an isolated voltage-sensing domain. Nat Struct Mol Biol. 2014;21(3):244–252. - PMC - PubMed
    1. Ramsey IS, Moran MM, Chong JA, Clapham DE. A voltage-gated proton-selective channel lacking the pore domain. Nature. 2006;440(7088):1213–1216. - PMC - PubMed

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