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Case Reports
. 2016 Mar;63(3):544-6.
doi: 10.1002/pbc.25796. Epub 2015 Oct 15.

Breast Cancer and Non-Hodgkin Lymphoma in a Young Male with Cowden Syndrome

Robert Tanner Hagelstrom  1 , James Ford  2 , Gwendolyn M Reiser  3 , Marilu Nelson  1 , Diane L Pickering  1 , Pamela A Althof  1 , Warren G Sanger  1 , Peter F Coccia  4
Affiliations
Case Reports

Breast Cancer and Non-Hodgkin Lymphoma in a Young Male with Cowden Syndrome

Robert Tanner Hagelstrom et al. Pediatr Blood Cancer. 2016 Mar.

Abstract

Male breast cancer (MBC) is unusual, especially in young adults. Most cases of MBC as a secondary malignancy relate to the previous treatment with ionizing radiation. MBC can be associated with mutations in hereditary cancer predisposition syndrome genes (i.e., BRCA2); however, no such association has been reported in patients with Cowden syndrome (involving the phosphatase and tensin homolog [PTEN] gene). We describe a patient with Cowden syndrome who was initially diagnosed with B-cell lymphoblastic lymphoma at the age of 7 years, then MBC at the age of 31 years, and never received radiation therapy.

Keywords: B-cell lymphoblastic lymphoma; Cowden syndrome; PTEN; male breast cancer.

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