Estimation of the Electrode-Fiber Bioelectrical Coupling From Extracellularly Recorded Single Fiber Action Potentials

Abstract

Selective peripheral neural interfaces are currently capable of detecting minute electrical signals from nearby nerve fibers as single fiber action potential (SFAP) waveforms. Each detected single unit has a distinct shape originating from the unique bioelectrical coupling that exists between the neuroprosthetic electrode, the nerve fiber and the extracellular milieu. The bioelectrical coupling manifests itself as a series of low-pass Bessel filters acting on the action currents along the nerve fiber. Here, we present a method to estimate the electrode-fiber bioelectrical coupling through a quantitative analysis of the spectral distribution of the single units extracellularly recorded with the thin-film longitudinal intrafascicular electrode (tfLIFE) in an in vivo mammalian peripheral nerve animal model. The bioelectrical coupling estimate is an estimate of the electrode sensitivity function traversed by the nerve fiber, suggesting that it is as a means to directly measure the spatial relationship between the nerve fiber and electrode. It not only reflects a shape change to the SFAP, but has implications for in situ nerve fiber location tracking, in situ diagnostics of nerves and neuroproshetic electrodes, and assessment of the biocompatibility of neural interfaces and the health of the reporting nerve fibers.