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Case Reports
. 2016 Jul-Sep;62(3):205-7.
doi: 10.4103/0022-3859.166181.

POEMS syndrome associated with plasmacytoma of the clivus: "Time discovers the truth"

J Thomas  1 , B V Maramattom  2 , J Varghese  3 , P M Kuruvilla  3
Affiliations
Case Reports

POEMS syndrome associated with plasmacytoma of the clivus: "Time discovers the truth"

J Thomas et al. J Postgrad Med. 2016 Jul-Sep.

Abstract

Polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes (POEMS) syndrome is characterized by the presence of a monoclonal plasma cell disorder, peripheral neuropathy, and one or more of the following features: Osteosclerotic myeloma, Castleman's disease (angiofollicular lymph node hyperplasia), increased levels of serum vascular endothelial growth factor (VEGF), organomegaly, endocrinopathy, edema, typical skin changes, and papilledema. [1] Solitary plasmacytomas most frequently occur in the bone but can also be found in soft tissues (extramedullary plasmacytoma). [2] We report a case that showed a rare association of POEMS syndrome with a plasmacytoma of the clivus.

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Figures

Figure 1
Figure 1
Germinal center with hyalinized blood vessels and mantle zone hyperplasia
Figure 2
Figure 2
Panel A. T1-weighted images showing a clival lesion. Panel B. Sagittal T1 postcontrast image showing lesion enhancement. Panel C. Axial T1 postcontrast image showing the clival lesion and displacement of the right internal carotid artery (ICA). Panel D. Diffusion-weighted magnetic resonance imaging (DW-MRI) showing multiple right hemispheric infarcts
See this image and copyright information in PMC

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