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Clinical Trial
. 1989 Mar;209(3):307-11.
doi: 10.1097/00000658-198903000-00010.

Antibiotic prophylaxis in acute nonperforated appendicitis. The Danish Multicenter Study Group III

T Bauer  1 , B Vennits, B Holm, J Hahn-Pedersen, D Lysen, H Galatius, E S Kristensen, P Graversen, F Wilhelmsen, H Skjoldborg, et al.
Affiliations
Clinical Trial

Antibiotic prophylaxis in acute nonperforated appendicitis. The Danish Multicenter Study Group III

T Bauer et al. Ann Surg. 1989 Mar.

Abstract

In a prospective, block-randomized, multicenter study, the safety and efficacy of cefoxitin in preoperative prophylaxis were studied. 1735 patients undergoing appendectomy were evaluable, and half of these patients received 2 g of cefoxitin before undergoing operation. The patients were divided into three groups: patients with a normal appendix, patients with an acutely inflamed appendix, and patients with a gangrenous appendix. The study showed for each group a significant reduction of the incidence of wound infection in patients receiving prophylaxis. However, intra-abdominal abscess formation was not influenced by preoperative antibiotic prophylaxis. Consequently, routine preoperative prophylaxis is recommended before appendectomy.

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