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Review
. 2015;9(12):1501-10.
doi: 10.1586/17474124.2015.1094372. Epub 2015 Oct 15.

Recent advances in the pathological understanding of eosinophilic esophagitis

Antonella Cianferoni  1   2 , Jonathan M Spergel  1   2 , Amanda Muir  2   3
Affiliations
Review

Recent advances in the pathological understanding of eosinophilic esophagitis

Antonella Cianferoni et al. Expert Rev Gastroenterol Hepatol. 2015.

Abstract

Eosinophilic esophagitis (EoE) is a chronic allergen-mediated inflammatory disease of the esophagus. This inflammation leads to feeding difficulties, failure to thrive and vomiting in young children, and causes food impaction and esophageal stricture in adolescents and adults. In the 20 years since EoE was first described, we have gained a great deal of knowledge regarding the genetic predisposition of disease, the inflammatory milieu associated with EoE and the long-term complications of chronic inflammation. Herein, we summarize the important breakthroughs in the field including both in vitro and in vivo analysis. We discuss insights that we have gained from large-scale unbiased genetic analysis, a multitude of genetically and chemically altered mouse models of EoE and most importantly, the results of clinical trials of various pharmacologic agents. Understanding these successes and failures may be the key to developing more effective therapeutic strategies.

Keywords: IL-13; T cells; eosinophilic esophagitis; fibrosis; thymic stromal lymphopoietin.

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References

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