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Clinical Trial
. 1989 Feb;120(2):261-6.
doi: 10.1111/j.1365-2133.1989.tb07791.x.

Ketanserin in the treatment of systemic sclerosis: a double-blind controlled trial

Affiliations
Clinical Trial

Ketanserin in the treatment of systemic sclerosis: a double-blind controlled trial

J P Ortonne et al. Br J Dermatol. 1989 Feb.

Abstract

In a randomized, double-blind study, the selective and specific S2-serotonergic receptor antagonist, ketanserin was compared with placebo in 24 patients with systemic sclerosis. Following a 6-week placebo washout period, patients were randomly allocated to receive ketanserin or placebo for 6 months. Ketanserin failed to produce a greater improvement than placebo in functional and objective clinical signs and symptoms as well as in most subjective assessments. However, in a global rating by the physician ketanserin was superior to placebo. No difference in the frequency or severity of side-effects was found. The results cast doubt on the hypothesis that serotonin may be a major contributing factor in the pathophysiology of systemic sclerosis.

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