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Comment
. 2015 Nov;25(11):634-636.
doi: 10.1016/j.tcb.2015.09.011. Epub 2015 Oct 21.

The InflammTORy Powers of Senescence

Manuel Serrano  1
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The InflammTORy Powers of Senescence

Manuel Serrano. Trends Cell Biol. 2015 Nov.

Abstract

Cellular senescence is accompanied by secretion of cytokines and ensuing inflammation. Recent work reveals that mTOR is crucial for the secretory phenotype of senescent cells. These findings open the possibility of disabling the pathological effects of senescence with mTOR inhibitors and may explain the anti-aging properties of rapamycin.

Keywords: aging; cancer; cytokines; inflammation; mTOR; senescence.

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