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. 2016 Jan;57(1):151-62.
doi: 10.2967/jnumed.115.159012. Epub 2015 Oct 15.

MIRD Pamphlet No. 26: Joint EANM/MIRD Guidelines for Quantitative 177Lu SPECT Applied for Dosimetry of Radiopharmaceutical Therapy

Michael Ljungberg  1 , Anna Celler  2 , Mark W Konijnenberg  3 , Keith F Eckerman  4 , Yuni K Dewaraja  5 , Katarina Sjögreen-Gleisner  6 ; SNMMI MIRD Committee; Wesley E Bolch, A Bertrand Brill, Frederic Fahey, Darrell R Fisher, Robert Hobbs, Roger W Howell, Ruby F Meredith, George Sgouros, Pat Zanzonico; EANM Dosimetry Committee; Klaus Bacher, Carlo Chiesa, Glenn Flux, Michael Lassmann, Lidia Strigari, Stephan Walrand
Affiliations
Free article

MIRD Pamphlet No. 26: Joint EANM/MIRD Guidelines for Quantitative 177Lu SPECT Applied for Dosimetry of Radiopharmaceutical Therapy

Michael Ljungberg et al. J Nucl Med. 2016 Jan.
Free article

Abstract

The accuracy of absorbed dose calculations in personalized internal radionuclide therapy is directly related to the accuracy of the activity (or activity concentration) estimates obtained at each of the imaging time points. MIRD Pamphlet no. 23 presented a general overview of methods that are required for quantitative SPECT imaging. The present document is next in a series of isotope-specific guidelines and recommendations that follow the general information that was provided in MIRD 23. This paper focuses on (177)Lu (lutetium) and its application in radiopharmaceutical therapy.

Keywords: SPECT/CT; endocrine; guideline; image processing; lutetium; oncology; quantitative SPECT; radiobiology/dosimetry; radionuclide therapy.

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