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. 2015;20(6-7):495-501.
doi: 10.3109/1354750X.2015.1094138. Epub 2015 Oct 15.

Neuroglobin and Nogo-a as biomarkers for the severity and prognosis of traumatic brain injury

Hao Chen  1 , He-Li Cao  1 , Shi-Wen Chen  1 , Yan Guo  1 , Wen-Wei Gao  1 , Heng-Li Tian  1 , Li-Xia Xue  2
Affiliations

Neuroglobin and Nogo-a as biomarkers for the severity and prognosis of traumatic brain injury

Hao Chen et al. Biomarkers. 2015.

Abstract

Objective: To identify the early changes of serum neuroglobin and Nogo-A concentrations and the relations to traumatic brain injury (TBI) severity and prognosis.

Methods: Serum samples were obtained and analyzed from 34 patients with TBI within the first 96 h after injury. Comparative analysis combined with Glasgow Coma Scale (GCS) scores and the 6-month prognosis of these patients was performed.

Results: Significant correlations were found between peak serum neuroglobin and Nogo-A concentrations and a patient's GCS score on admission (p < 0.001). The mean peak serum neuroglobin and Nogo-A concentrations were both significantly higher in patients with an unfavorable outcome at 6 months after injury (p < 0.05).

Conclusions: Serum neuroglobin and Nogo-A levels could be suggested as biomarkers for predicting TBI severity and prognosis.

Keywords: Biomarker; Nogo-A; neuroglobin; prognosis; traumatic brain injury.

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