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Case Reports
. 2016 Apr;181(3-4):273-7.
doi: 10.1007/s11046-015-9954-6. Epub 2015 Oct 16.

The First Case of Total Dystrophic Onychomycosis Caused by Aspergillus clavatus Resistant to Antifungal Drugs

Mehraban Falahati  1 , Aynaz Ghojoghi  1 , Mahdi Abastabar  2 , Zeinab Ghasemi  3 , Shirin Farahyar  1 , Maryam Roudbary  1 , Mohammad Taghi Hedayati  4 , Mojtaba Taghizadeh Armaki  4 , Akbar Hoseinnejad  4
Affiliations
Case Reports

The First Case of Total Dystrophic Onychomycosis Caused by Aspergillus clavatus Resistant to Antifungal Drugs

Mehraban Falahati et al. Mycopathologia. 2016 Apr.

Abstract

Onychomycosis is a common fungal infection of nails which is mainly caused by dermatophyte species and less often by yeasts and non-dermatophyte molds. We present a case of onychomycosis due to Aspergillus clavatus for the first time worldwide. The patient was an immunocompetent 32-year-old woman who identified with Psoriasis of the nail. The presence of A. clavatus in a nail sample was confirmed using microscopic and culture analysis followed by PCR of the β-tubulin gene. After antifungal susceptibility test, it is revealed that the isolate was resistant to the majority of common antifungal drugs, but finally the patient was treated with itraconazole 200 mg daily. A. clavatus and drug-resistant A. clavatus have not previously been reported from onychomycosis.

Keywords: Aspergillus clavatus; PCR of the β-tubulin gene; Resistant to antifungal drugs.

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References

    1. Med Mycol Case Rep. 2012 Jul 03;1(1):45-8 - PubMed
    1. J Clin Microbiol. 2004 Feb;42(2):914-6 - PubMed
    1. Rev Infect Dis. 1986 Sep-Oct;8(5):781-5 - PubMed
    1. Ann Dermatol. 2012 May;24(2):175-80 - PubMed
    1. An Bras Dermatol. 2014 Mar-Apr;89(2):312-7 - PubMed

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