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Review
. 1989 Mar:80:17-23.
doi: 10.1289/ehp.898017.

Coupling growth arrest and adipocyte differentiation

G Ailhaud  1 , C Dani, E Z Amri, P Djian, C Vannier, A Doglio, C Forest, D Gaillard, R Négrel, P Grimaldi
Affiliations
Review

Coupling growth arrest and adipocyte differentiation

G Ailhaud et al. Environ Health Perspect. 1989 Mar.

Abstract

The complete differentiation program of preadipose cells can be divided into early and late events. The expression of early markers takes place at growth arrest (G1/S boundary), whereas that of late markers, leading to terminal differentiation, takes place after a limited number of mitoses of early marker-containing cells. Only terminal differentiation requires the presence of growth hormone and triiodothyronine and results in the formation of triacylglycerol-filled, nondividing cells. The events of adipose cell differentiation which take place in vitro allow a better understanding of the development of adipose tissue in vivo.

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