Translational Research and Functional Changes in Voiding Function in Older Adults

doi:10.1016/j.cger.2015.06.001

Review

. 2015 Nov;31(4):535-48.

doi: 10.1016/j.cger.2015.06.001. Epub 2015 Jul 23.

Translational Research and Functional Changes in Voiding Function in Older Adults

Florenta Aura Kullmann¹, Lori Ann Birder², Karl-Erik Andersson³

Affiliations

¹ Renal-Electrolyte Division, Medicine Department, University of Pittsburgh School of Medicine, 3500 Terrace Street, A1220 Scaife Hall, Pittsburgh, PA 15261, USA.
² Renal-Electrolyte Division, Medicine Department, University of Pittsburgh School of Medicine, 3500 Terrace Street, A1207 Scaife Hall, Pittsburgh, PA 15261, USA; Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15213, USA.
³ Department of Urology, Institute for Regenerative Medicine, Wake Forest Baptist Medical Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA; AIAS, Aarhus Institute of Advanced Studies, Aarhus University, Høegh-Guldbergs Gade 6B, Building 1632, Aarhus C 8000, Denmark. Electronic address: kea@aias.au.dk.

PMID: 26476114
PMCID: PMC4865381
DOI: 10.1016/j.cger.2015.06.001

Review

Translational Research and Functional Changes in Voiding Function in Older Adults

Florenta Aura Kullmann et al. Clin Geriatr Med. 2015 Nov.

. 2015 Nov;31(4):535-48.

doi: 10.1016/j.cger.2015.06.001. Epub 2015 Jul 23.

Authors

Florenta Aura Kullmann¹, Lori Ann Birder², Karl-Erik Andersson³

Affiliations

¹ Renal-Electrolyte Division, Medicine Department, University of Pittsburgh School of Medicine, 3500 Terrace Street, A1220 Scaife Hall, Pittsburgh, PA 15261, USA.
² Renal-Electrolyte Division, Medicine Department, University of Pittsburgh School of Medicine, 3500 Terrace Street, A1207 Scaife Hall, Pittsburgh, PA 15261, USA; Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15213, USA.
³ Department of Urology, Institute for Regenerative Medicine, Wake Forest Baptist Medical Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA; AIAS, Aarhus Institute of Advanced Studies, Aarhus University, Høegh-Guldbergs Gade 6B, Building 1632, Aarhus C 8000, Denmark. Electronic address: kea@aias.au.dk.

PMID: 26476114
PMCID: PMC4865381
DOI: 10.1016/j.cger.2015.06.001

Abstract

Age-related LUT dysfunctions result from complex processes controlled by multiple genetic, epigenetic, and environmental factors and account for high costs of health care. This article discusses risk factors that may play a role in age-related LUT dysfunction and presents available data comparing structural and functional changes that occur with aging in the bladder of humans and animal models. A better understanding of factors and mechanisms underlying LUT symptoms in the older population may lead to therapeutic interventions to reduce these dysfunctions.

Keywords: Animal models; Ischemia; LUTS; Overactive bladder; Underactive detrusor; Urinary bladder; Urinary incontinence; Voiding dysfunctions.

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References

1. Andersson KE. Storage and voiding symptoms: Pathophysiologic aspects. Urology. 2003;62:3–10. - PubMed
1. Andersson KE. LUTS treatment: Future treatment options. Neurourology and urodynamics. 2007;26:934–947. - PubMed
1. Irwin DE, Kopp ZS, Agatep B, et al. Worldwide prevalence estimates of lower urinary tract symptoms, overactive bladder, urinary incontinence and bladder outlet obstruction. BJU international. 2011;108:1132–1138. - PubMed
1. Coyne KS, Wein A, Nicholson S, et al. Comorbidities and personal burden of urgency urinary incontinence: A systematic review. International journal of clinical practice. 2013;67:1015–1033. - PubMed
1. Yoshida M. Perspectives on overactive bladder in the elderly population. World journal of urology. 2009;27:729–737. - PubMed

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[1] Andersson KE. Storage and voiding symptoms: Pathophysiologic aspects. Urology. 2003;62:3–10. - PubMed

[2] Andersson KE. Storage and voiding symptoms: Pathophysiologic aspects. Urology. 2003;62:3–10. - PubMed

[3] Andersson KE. LUTS treatment: Future treatment options. Neurourology and urodynamics. 2007;26:934–947. - PubMed

[4] Andersson KE. LUTS treatment: Future treatment options. Neurourology and urodynamics. 2007;26:934–947. - PubMed

[5] Irwin DE, Kopp ZS, Agatep B, et al. Worldwide prevalence estimates of lower urinary tract symptoms, overactive bladder, urinary incontinence and bladder outlet obstruction. BJU international. 2011;108:1132–1138. - PubMed

[6] Irwin DE, Kopp ZS, Agatep B, et al. Worldwide prevalence estimates of lower urinary tract symptoms, overactive bladder, urinary incontinence and bladder outlet obstruction. BJU international. 2011;108:1132–1138. - PubMed

[7] Coyne KS, Wein A, Nicholson S, et al. Comorbidities and personal burden of urgency urinary incontinence: A systematic review. International journal of clinical practice. 2013;67:1015–1033. - PubMed

[8] Coyne KS, Wein A, Nicholson S, et al. Comorbidities and personal burden of urgency urinary incontinence: A systematic review. International journal of clinical practice. 2013;67:1015–1033. - PubMed

[9] Yoshida M. Perspectives on overactive bladder in the elderly population. World journal of urology. 2009;27:729–737. - PubMed

[10] Yoshida M. Perspectives on overactive bladder in the elderly population. World journal of urology. 2009;27:729–737. - PubMed

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Translational Research and Functional Changes in Voiding Function in Older Adults

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Translational Research and Functional Changes in Voiding Function in Older Adults

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