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Review
. 1989 Mar;50(3):81-6.

Lithium: a therapeutic magic wand

Affiliations
  • PMID: 2647710
Review

Lithium: a therapeutic magic wand

J W Jefferson. J Clin Psychiatry. 1989 Mar.

Abstract

The premodern and modern history of lithium in medicine spans 130 years. While today the drug has a firmly established role in psychiatry, many issues have yet to be fully resolved. Discussed within (but still not fully resolved) are the effectiveness of lithium in treatment-resistant depression, whether a rebound relapse occurs following abrupt discontinuation, which serum levels are most desirable for acute and maintenance therapy, whether a certain dosage schedule is kinder to the kidney, the relationship of dosage schedule to 12-hour serum level, how to best monitor thyroid function, whether lithium causes kidney rot, and whether lithium and neuroleptics make a uniquely neurotoxic combination.

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Comment in

  • Lithium therapy and prophylaxis.
    Andrade C, Pradhan N. Andrade C, et al. J Clin Psychiatry. 1990 Jan;51(1):37-8. J Clin Psychiatry. 1990. PMID: 2295594 No abstract available.

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