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. 2015 Nov;22(11):920-3.
doi: 10.1038/nsmb.3111. Epub 2015 Oct 19.

Stage-specific assembly events of the 6-MDa small-subunit processome initiate eukaryotic ribosome biogenesis

Malik Chaker-Margot  1   2 , Mirjam Hunziker  1 , Jonas Barandun  1 , Brian D Dill  3 , Sebastian Klinge  1
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Stage-specific assembly events of the 6-MDa small-subunit processome initiate eukaryotic ribosome biogenesis

Malik Chaker-Margot et al. Nat Struct Mol Biol. 2015 Nov.

Abstract

Eukaryotic ribosome biogenesis involves a plethora of ribosome-assembly factors, and their temporal order of association with preribosomal RNA is largely unknown. By using Saccharomyces cerevisiae as a model organism, we developed a system that recapitulates and arrests ribosome assembly at early stages, thus providing in vivo snapshots of nascent preribosomal particles. Here we report the stage-specific order in which 70 ribosome-assembly factors associate with preribosomal RNA domains, thereby forming the 6-MDa small-subunit processome.

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References

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