Theoretical considerations for understanding a Purkinje cell timing mechanism

doi:10.4161/19420889.2014.994376

. 2014 Dec 31;7(6):e994376.

doi: 10.4161/19420889.2014.994376. eCollection 2014 Dec.

Theoretical considerations for understanding a Purkinje cell timing mechanism

Fredrik Johansson¹, Germund Hesslow¹

Affiliations

Affiliation

¹ Associative Learning Group; Department of Experimental Medical Science; Lund University ; Lund, Sweden ; The Linnaeus Center Thinking in Time: Cognition; Communication & Learning; Lund University ; Lund, Sweden.

PMID: 26479712
PMCID: PMC4594589
DOI: 10.4161/19420889.2014.994376

Theoretical considerations for understanding a Purkinje cell timing mechanism

Fredrik Johansson et al. Commun Integr Biol. 2014.

. 2014 Dec 31;7(6):e994376.

doi: 10.4161/19420889.2014.994376. eCollection 2014 Dec.

Authors

Fredrik Johansson¹, Germund Hesslow¹

Affiliation

¹ Associative Learning Group; Department of Experimental Medical Science; Lund University ; Lund, Sweden ; The Linnaeus Center Thinking in Time: Cognition; Communication & Learning; Lund University ; Lund, Sweden.

PMID: 26479712
PMCID: PMC4594589
DOI: 10.4161/19420889.2014.994376

Abstract

In classical conditioning, cerebellar Purkinje cells learn an adaptively timed pause in spontaneous firing. This pause reaches its maximum near the end of the interstimulus interval. While it was thought that this timing was due to temporal patterns in the input signal and selective engagement of changes in synapse strength, we have shown Purkinje cells learn timed responses even when the conditional stimulus is delivered to its immediate afferents.(1) This shows that Purkinje cells have a cellular timing mechanism. The cellular models of intrinsic timing we are aware of are based on adapting the rise time of the concentration of a given ion. As an alternative, we here propose a selection mechanism in abstract terms for how a Purkinje cell could learn to respond at a particular time after an external trigger.

Keywords: cerebellum; control; eyeblink conditioning; glutamate transmission; purkinje cell; temporal timing.

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Learned response sequences in cerebellar Purkinje cells.
Jirenhed DA, Rasmussen A, Johansson F, Hesslow G. Jirenhed DA, et al. Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):6127-6132. doi: 10.1073/pnas.1621132114. Epub 2017 May 22. Proc Natl Acad Sci U S A. 2017. PMID: 28533379 Free PMC article.
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References

1. Johansson F., Jirenhed D. A., Rasmussen A., Zucca R., Hesslow G. Memory trace and timing mechanism localized to cerebellar Purkinje cells. Pro Natl Acad Sci U S A ;http://dx.doi.org/10.1073/pnas.1415371111 (2014); PMID:25267641 - DOI - PMC - PubMed
1. Kehoe E. J., Macrae M. in A Neuroscientist's Guide to Classical Conditioning (ed J. W. Moore) 171-231 (New York: Springer-Verlag, 2002) .
1. Hesslow G., Ivarsson M. Suppression of cerebellar Purkinje cells during conditioned responses in ferrets. Neuroreport 5, 649-652 (1994); PMID:8025262 - PubMed
1. Jirenhed D. A., Bengtsson F., Hesslow G. Acquisition, extinction, and reacquisition of a cerebellar cortical memory trace. J Neurosci 27, 2493-2502 (2007); PMID:17344387 - PMC - PubMed
1. Jirenhed D. A., Hesslow G. Learning Stimulus Intervals – Adaptive Timing of Conditioned Purkinje Cell Responses. Cerebellum 10, 523-535 (2011); PMID:21416378 - PubMed

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[1] Johansson F., Jirenhed D. A., Rasmussen A., Zucca R., Hesslow G. Memory trace and timing mechanism localized to cerebellar Purkinje cells. Pro Natl Acad Sci U S A ;http://dx.doi.org/10.1073/pnas.1415371111 (2014); PMID:25267641 - DOI - PMC - PubMed

[2] Johansson F., Jirenhed D. A., Rasmussen A., Zucca R., Hesslow G. Memory trace and timing mechanism localized to cerebellar Purkinje cells. Pro Natl Acad Sci U S A ;http://dx.doi.org/10.1073/pnas.1415371111 (2014); PMID:25267641 - DOI - PMC - PubMed

[3] Kehoe E. J., Macrae M. in A Neuroscientist's Guide to Classical Conditioning (ed J. W. Moore) 171-231 (New York: Springer-Verlag, 2002) .

[4] Kehoe E. J., Macrae M. in A Neuroscientist's Guide to Classical Conditioning (ed J. W. Moore) 171-231 (New York: Springer-Verlag, 2002) .

[5] Hesslow G., Ivarsson M. Suppression of cerebellar Purkinje cells during conditioned responses in ferrets. Neuroreport 5, 649-652 (1994); PMID:8025262 - PubMed

[6] Hesslow G., Ivarsson M. Suppression of cerebellar Purkinje cells during conditioned responses in ferrets. Neuroreport 5, 649-652 (1994); PMID:8025262 - PubMed

[7] Jirenhed D. A., Bengtsson F., Hesslow G. Acquisition, extinction, and reacquisition of a cerebellar cortical memory trace. J Neurosci 27, 2493-2502 (2007); PMID:17344387 - PMC - PubMed

[8] Jirenhed D. A., Bengtsson F., Hesslow G. Acquisition, extinction, and reacquisition of a cerebellar cortical memory trace. J Neurosci 27, 2493-2502 (2007); PMID:17344387 - PMC - PubMed

[9] Jirenhed D. A., Hesslow G. Learning Stimulus Intervals – Adaptive Timing of Conditioned Purkinje Cell Responses. Cerebellum 10, 523-535 (2011); PMID:21416378 - PubMed

[10] Jirenhed D. A., Hesslow G. Learning Stimulus Intervals – Adaptive Timing of Conditioned Purkinje Cell Responses. Cerebellum 10, 523-535 (2011); PMID:21416378 - PubMed

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Theoretical considerations for understanding a Purkinje cell timing mechanism

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Theoretical considerations for understanding a Purkinje cell timing mechanism

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