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. 2015 Oct 19;60(1):621-3.
doi: 10.1128/AAC.01211-15. Print 2016 Jan.

Multidrug-Resistant Neisseria gonorrhoeae Isolates from Nanjing, China, Are Sensitive to Killing by a Novel DNA Gyrase Inhibitor, ETX0914 (AZD0914)

Xiao-Hong Su  1 , Bao-Xi Wang  2 , Wen-Jing Le  1 , Yu-Rong Liu  1 , Chuan Wan  1 , Sai Li  1 , Richard A Alm  3 , John P Mueller  4 , Peter A Rice  5
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Multidrug-Resistant Neisseria gonorrhoeae Isolates from Nanjing, China, Are Sensitive to Killing by a Novel DNA Gyrase Inhibitor, ETX0914 (AZD0914)

Xiao-Hong Su et al. Antimicrob Agents Chemother. .

Abstract

We tested the activity of ETX0914 against 187 Neisseria gonorrhoeae isolates from men with urethritis in Nanjing, China, in 2013. The MIC50, MIC90, and MIC range for ETX0914 were 0.03 μg/ml, 0.06 μg/ml, and ≤0.002 to 0.125 μg/ml, respectively. All isolates were resistant to ciprofloxacin, and 36.9% (69/187) were resistant to azithromycin. Of the isolates, 46.5% were penicillinase-producing N. gonorrhoeae (PPNG), 36% were tetracycline-resistant N. gonorrhoeae (TRNG), and 13% (24 isolates) had an MIC of 0.125 μg/ml for ceftriaxone. ETX0914 may be an effective treatment option for gonorrhea.

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Figures

FIG 1
FIG 1
MIC distributions of ETX0914 and ciprofloxacin for 187 clinical N. gonorrhoeae isolates.
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References

    1. Unemo M, Golparian D, Syversen G, Vestrheim DF, Moi H. 2010. Two cases of verified clinical failures using internationally recommended first-line cefixime for gonorrhoea treatment, Norway, 2010. Euro Surveill 15:pii=19721 http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19721. - PubMed
    1. Ison CA, Hussey J, Sankar KN, Evans J, Alexander S. 2011. Gonorrhoea treatment failures to cefixime and azithromycin in England, 2010. Euro Surveill 16:pii=19833 http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19933. - PubMed
    1. Unemo M, Golparian D, Stary A, Eigentler A. 2011. First Neisseria gonorrhoeae strain with resistance to cefixime causing gonorrhoea treatment failure in Austria, 2011. Euro Surveill 216:pii=19998 http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19998. - PubMed
    1. Unemo M, Golparian D, Nicholas R, Ohnishi M, Gallay A, Sednaoui P. 2012. High-level cefixime- and ceftriaxone-resistant Neisseria gonorrhoeae in France: novel penA mosaic allele in a successful international clone causes treatment failure. Antimicrob Agents Chemother 56:1273–1280. doi:10.1128/AAC.05760-11. - DOI - PMC - PubMed
    1. Allen VG, Mitterni L, Seah C, Rebbapragada A, Martin IE, Lee C, Siebert H, Towns L, Melano RG, Low DE. 2013. Neisseria gonorrhoeae treatment failure and susceptibility to cefixime in Toronto, Canada. JAMA 309:163–170. doi:10.1001/jama.2012.176575. - DOI - PubMed

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