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. 2015 Oct 19;60(1):621-3.
doi: 10.1128/AAC.01211-15. Print 2016 Jan.

Multidrug-Resistant Neisseria gonorrhoeae Isolates from Nanjing, China, Are Sensitive to Killing by a Novel DNA Gyrase Inhibitor, ETX0914 (AZD0914)

Xiao-Hong Su  1 , Bao-Xi Wang  2 , Wen-Jing Le  1 , Yu-Rong Liu  1 , Chuan Wan  1 , Sai Li  1 , Richard A Alm  3 , John P Mueller  4 , Peter A Rice  5
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Multidrug-Resistant Neisseria gonorrhoeae Isolates from Nanjing, China, Are Sensitive to Killing by a Novel DNA Gyrase Inhibitor, ETX0914 (AZD0914)

Xiao-Hong Su et al. Antimicrob Agents Chemother. .

Abstract

We tested the activity of ETX0914 against 187 Neisseria gonorrhoeae isolates from men with urethritis in Nanjing, China, in 2013. The MIC50, MIC90, and MIC range for ETX0914 were 0.03 μg/ml, 0.06 μg/ml, and ≤0.002 to 0.125 μg/ml, respectively. All isolates were resistant to ciprofloxacin, and 36.9% (69/187) were resistant to azithromycin. Of the isolates, 46.5% were penicillinase-producing N. gonorrhoeae (PPNG), 36% were tetracycline-resistant N. gonorrhoeae (TRNG), and 13% (24 isolates) had an MIC of 0.125 μg/ml for ceftriaxone. ETX0914 may be an effective treatment option for gonorrhea.

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Figures

FIG 1
FIG 1
MIC distributions of ETX0914 and ciprofloxacin for 187 clinical N. gonorrhoeae isolates.
See this image and copyright information in PMC

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