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Randomized Controlled Trial
. 2015 Nov;19(9):901-7.
doi: 10.1007/s12603-015-0558-0.

Nutritional Guidance Improves Nutrient Intake and Quality of Life, and May Prevent Falls in Aged Persons with Alzheimer Disease Living with a Spouse (NuAD Trial)

M H Suominen  1 , T M Puranen, S K Jyväkorpi, U Eloniemi-Sulkava, H Kautiainen, U Siljamäki-Ojansuu, K H Pitkalä
Affiliations
Randomized Controlled Trial

Nutritional Guidance Improves Nutrient Intake and Quality of Life, and May Prevent Falls in Aged Persons with Alzheimer Disease Living with a Spouse (NuAD Trial)

M H Suominen et al. J Nutr Health Aging. 2015 Nov.

Abstract

Objective: The aim was to examine the effect of tailored nutritional guidance on nutrition, health-related quality of life (HRQoL) and falls in persons with Alzheimer disease (AD).

Design: Randomised controlled trial.

Setting and participants: Persons with AD living with a spouse.

Intervention: Tailored nutritional guidance with home visits during one year. The control group received a written guide about nutrition in older adults and all community-provided normal care.

Measurements: The primary outcome measure was weight change, and secondary outcomes included changes in protein and micronutrient intakes from three-day food records, HRQoL (15D) and rate of falls.

Results: Of the participants (n = 78) with AD (mean age 77.4, 69% males), 40% were at risk for malnutrition, 77% received < 1.2 g/bodyweight (kg) of protein at baseline. We found no difference in weight change between the groups. At 12 months, the mean change in protein intake was 0.05 g/bodyweight (kg) (95% CI -0.06 to 0.15) in the intervention group (IG), and -0.06 g/kg (95% CI -0.12 to 0.02) in the control group (CG) (p = 0.031, adjusted for baseline value, age, sex, MMSE and BMI). Participants' HRQoL improved by 0.006 (95% CI -0.016 to 0.028) in the IG, but declined by -0.036 (95% CI -0.059 to 0.013) in the CG (p = 0.007, adjusted for baseline value, age, sex, MMSE and BMI). Dimensions that differed included mental functioning, breathing, usual activities and depression. The fall rate was 0.55 falls/person per year (95% CI 0.34 to 0.83) in the IG, and 1.39 falls/person per year (95% CI 1.04 to 1.82) in the CG (IRR 0.55; 95% CI 2.16 to 6.46; p < 0.001 adjusted for age, sex and MMSE).

Conclusions: Tailored nutritional guidance improves nutrition and HRQoL, and may prevent falls among AD people living with a spouse.

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Figures

Figure 1
Figure 1
Figure 2
Figure 2
Changes in quality of life in the intervention and control groups. Adjusted to baseline value, age, sex, MMSE and BMI
See this image and copyright information in PMC

References

    1. Guerin O., Andrieu S., Schneider S.M., et al. Different modes of weight loss in Alzheimer disease: a prospective study of 395 patients. Am J Clin Nutr. 2005;82:435–441. PubMed PMID: 16087990. - PubMed
    1. Soto M.E., Secher M., Gillette-Guyonnet S., et al. Weight loss and rapid cognitive decline in community-dwelling patients with Alzheimer’s disease. J Alzheimers Dis. 2012;28:647–654. PubMed PMID: 22045479. - PubMed
    1. Pedersen A.N., Ovesen L., Schroll M., Avlund K., Era P. Body composition of 80-years old men and women and its relation to muscle strength. physical activity and functional ability J Nutr Health Aging. 2002;6:413–420. PubMed PMID: 12459892. - PubMed
    1. White H., Pieper C., Schmader K. The association of weight change in Alzheimer’s disease with severity of disease and mortality: a longitudinal analysis. J Am Geriatr Soc. 1998;46:1232–1234. 10.1111/j.1532-5415.1998.tb04537.x - DOI - PubMed
    1. Rivière S., Gillette-Guyonnet S., Voisin T., et al. A nutritional education program could prevent weight loss and slow cognitive decline in Alzheimer’s disease. J Nutr Health Aging. 2001;5:295–299. PubMed PMID: 11753499. - PubMed

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