Review

. 2015 Dec;17(12):110.

doi: 10.1007/s11886-015-0666-9.

Risk Stratification for Primary Prevention of Coronary Artery Disease: Roles of C-Reactive Protein and Coronary Artery Calcium

Waqas T Qureshi¹, Jamal S Rana^{2

3

4}, Joseph Yeboah⁵, Usama Bin Nasir⁵, Mouaz H Al-Mallah^{6

7}

Affiliations

¹ Division of Cardiovascular Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC, 27157, USA. WQureshi@wakehealth.edu.
² Division of Cardiology, Kaiser Permanente Northern California, Oakland, CA, 94609, USA.
³ Department of Medicine, University of California, San Francisco, San Francisco, CA, 94143, USA.
⁴ Division of Research, Kaiser Permanente Northern California, Oakland, CA, 94609, USA.
⁵ Division of Cardiovascular Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC, 27157, USA.
⁶ Cardiac Imaging King Abdul-Aziz Cardiac Center, Riyadh, Kingdom of Saudi Arabia.
⁷ King Abdullah International Medical research center, Riyadh, Kingdom of Saudi Arabia.

PMID: 26482753
DOI: 10.1007/s11886-015-0666-9

Review

Risk Stratification for Primary Prevention of Coronary Artery Disease: Roles of C-Reactive Protein and Coronary Artery Calcium

Waqas T Qureshi et al. Curr Cardiol Rep. 2015 Dec.

. 2015 Dec;17(12):110.

doi: 10.1007/s11886-015-0666-9.

Authors

Waqas T Qureshi¹, Jamal S Rana^{2

3

4}, Joseph Yeboah⁵, Usama Bin Nasir⁵, Mouaz H Al-Mallah^{6

7}

Affiliations

¹ Division of Cardiovascular Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC, 27157, USA. WQureshi@wakehealth.edu.
² Division of Cardiology, Kaiser Permanente Northern California, Oakland, CA, 94609, USA.
³ Department of Medicine, University of California, San Francisco, San Francisco, CA, 94143, USA.
⁴ Division of Research, Kaiser Permanente Northern California, Oakland, CA, 94609, USA.
⁵ Division of Cardiovascular Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC, 27157, USA.
⁶ Cardiac Imaging King Abdul-Aziz Cardiac Center, Riyadh, Kingdom of Saudi Arabia.
⁷ King Abdullah International Medical research center, Riyadh, Kingdom of Saudi Arabia.

PMID: 26482753
DOI: 10.1007/s11886-015-0666-9

Abstract

Risk stratification of individuals at risk for atherosclerotic cardiovascular disease (ASCVD) plays an important role in primary prevention of cardiovascular disease. In addition to risk scores derived from conventional cardiovascular risk factors, high sensitivity C-reactive protein (hs-CRP) and coronary artery calcium (CAC) have emerged as two of the widely accepted non traditional risk factors for atherosclerotic disease that have shown incremental prognostic value in predicting cardiovascular events. This review systematically assesses the role of hs-CRP and CAC in various studies and demonstrates meta-analyses of the incremental prognostic value of hs-CRP and CAC in identifying patients at risk of future CVD events. Compared with this, CAC showed better incremental prognostic value and might be a better indicator of ASCVD risk in asymptomatic adults.

Keywords: Cholesterol treatment; Coronary artery calcium; Epidemiology; High sensitivity C reactive protein; Review; Risk factors; Statin therapy.

PubMed Disclaimer

Cited by

2024 Guidelines of the Taiwan Society of Cardiology on the Primary Prevention of Atherosclerotic Cardiovascular Disease --- Part I.
Chao TH, Lin TH, Cheng CI, Wu YW, Ueng KC, Wu YJ, Lin WW, Leu HB, Cheng HM, Huang CC, Wu CC, Lin CF, Chang WT, Pan WH, Chen PR, Ting KH, Su CH, Chu CS, Chien KL, Yen HW, Wang YC, Su TC, Liu PY, Chang HY, Chen PW, Juang JJ, Lu YW, Lin PL, Wang CP, Ko YS, Chiang CE, Hou CJ, Wang TD, Lin YH, Huang PH, Chen WJ. Chao TH, et al. Acta Cardiol Sin. 2024 Sep;40(5):479-543. doi: 10.6515/ACS.202409_40(5).20240724A. Acta Cardiol Sin. 2024. PMID: 39308649 Free PMC article.
2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
Arnett DK, Blumenthal RS, Albert MA, Buroker AB, Goldberger ZD, Hahn EJ, Himmelfarb CD, Khera A, Lloyd-Jones D, McEvoy JW, Michos ED, Miedema MD, Muñoz D, Smith SC Jr, Virani SS, Williams KA Sr, Yeboah J, Ziaeian B. Arnett DK, et al. J Am Coll Cardiol. 2019 Sep 10;74(10):e177-e232. doi: 10.1016/j.jacc.2019.03.010. Epub 2019 Mar 17. J Am Coll Cardiol. 2019. PMID: 30894318 Free PMC article. No abstract available.
Combining Biomarkers and Imaging for Short-Term Assessment of Cardiovascular Disease Risk in Apparently Healthy Adults: A Paradigm-Shifting Approach?
Osei AD, Blaha MJ. Osei AD, et al. J Am Heart Assoc. 2020 Aug 4;9(15):e017790. doi: 10.1161/JAHA.120.017790. Epub 2020 Jul 23. J Am Heart Assoc. 2020. PMID: 32698709 Free PMC article. No abstract available.
2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
Arnett DK, Blumenthal RS, Albert MA, Buroker AB, Goldberger ZD, Hahn EJ, Himmelfarb CD, Khera A, Lloyd-Jones D, McEvoy JW, Michos ED, Miedema MD, Muñoz D, Smith SC Jr, Virani SS, Williams KA Sr, Yeboah J, Ziaeian B. Arnett DK, et al. Circulation. 2019 Sep 10;140(11):e596-e646. doi: 10.1161/CIR.0000000000000678. Epub 2019 Mar 17. Circulation. 2019. PMID: 30879355 Free PMC article. Review. No abstract available.
High-Sensitivity C-Reactive Protein Discordance With Atherogenic Lipid Measures and Incidence of Atherosclerotic Cardiovascular Disease in Primary Prevention: The ARIC Study.
Quispe R, Michos ED, Martin SS, Puri R, Toth PP, Al Suwaidi J, Banach M, Virani SS, Blumenthal RS, Jones SR, Elshazly MB. Quispe R, et al. J Am Heart Assoc. 2020 Feb 4;9(3):e013600. doi: 10.1161/JAHA.119.013600. Epub 2020 Jan 30. J Am Heart Assoc. 2020. PMID: 32013698 Free PMC article.

See all "Cited by" articles

References

1. N Engl J Med. 2008 Mar 27;358(13):1336-45 - PubMed
1. Lancet. 1997 Feb 15;349(9050):462-6 - PubMed
1. Cardiovasc Res. 2001 Nov;52(2):281-9 - PubMed
1. Circulation. 2007 Feb 27;115(8):981-9 - PubMed
1. BMJ. 2012 May 24;344:e3318 - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- Springer
Medical
- MedlinePlus Health Information
Research Materials
- NCI CPTC Antibody Characterization Program
Miscellaneous
- NCI CPTAC Assay Portal

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Risk Stratification for Primary Prevention of Coronary Artery Disease: Roles of C-Reactive Protein and Coronary Artery Calcium

Affiliations

Risk Stratification for Primary Prevention of Coronary Artery Disease: Roles of C-Reactive Protein and Coronary Artery Calcium

Authors

Affiliations

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Research Materials

Miscellaneous

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Related information

LinkOut - more resources

Full Text Sources

Medical

Research Materials

Miscellaneous