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Review
. 2015 Nov;26(11):592-594.
doi: 10.1016/j.tem.2015.09.002. Epub 2015 Oct 16.

Copernicus Revisited: Overturning Ptolemy's View of the GPER Universe

Ross D Feldman  1 , Lee E Limbird  2
Affiliations
Review

Copernicus Revisited: Overturning Ptolemy's View of the GPER Universe

Ross D Feldman et al. Trends Endocrinol Metab. 2015 Nov.

Abstract

Whether aldosterone activates the G-protein-coupled estrogen receptor (GPER) has been questioned, recently, in the name of Copernicus. However, for G-protein-coupled receptors (GPCRs) multiple hormone activators are common. Further, studies in mineralocorticoid receptor (MR)-deficient systems, with pharmacological GPER-selective antagonists or regulation of GPER expression, consistently show that some aldosterone effects can be GPER mediated.

Keywords: GPCR; GPER; aldosterone; estrogen.

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