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Case Reports
. 2015 Oct 15;7(10):259-62.
doi: 10.4251/wjgo.v7.i10.259.

Paraneoplastic leukemoid reaction in pancreatic cancer: A case report

Mélanie Dos Santos  1 , Karine Bouhier  1 , Manh-Thong Dao  1
Affiliations
Case Reports

Paraneoplastic leukemoid reaction in pancreatic cancer: A case report

Mélanie Dos Santos et al. World J Gastrointest Oncol. .

Abstract

Paraneoplastic leukemoid reaction is a rare syndrome defined by a leukocyte count exceeding 50 Giga/Liter (G/L), mostly described with progressive lung or renal carcinoma. We report a case of a 68-year-old man with recurrent pancreatic carcinoma presenting a leukemoid reaction with a white blood cell count of 63.87 G/L without identified infectious, iatrogenic or hematologic causes. His overall condition quickly degraded and he died three weeks after the discovery of the leukemoid reaction. This is the first case in French literature of leukemoid reaction in a patient with pancreatic carcinoma with poor prognostic value.

Keywords: Leukemoid reaction; Pancreatic neoplasms; Paraneoplastic syndrome; Prognosis.

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Figures

Figure 1
Figure 1
Computer tomography before (A) and after (B) leukemoid reaction. Pancreatic and hepatic evolution.
Figure 2
Figure 2
Evolution of white blood cell counts associated with leukemoid reaction. Leukocytosis rapid increase.
Figure 3
Figure 3
Bone marrow cytology (original magnification × 500). Increased granulopoiesis up to the neutrophils with a complete maturation and without blast cells.
See this image and copyright information in PMC

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