Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Dec;7(4):234-7.
doi: 10.1016/j.slsci.2014.10.002. Epub 2014 Oct 30.

Sleep disorders: A review of the interface between restless legs syndrome and iron metabolism

Paulo Daubian-Nosé  1 , Miriam K Frank  1 , Andrea Maculano Esteves  1
Affiliations
Review

Sleep disorders: A review of the interface between restless legs syndrome and iron metabolism

Paulo Daubian-Nosé et al. Sleep Sci. 2014 Dec.

Abstract

Restless legs syndrome (RLS) is characterized by unpleasant sensations mainly in the legs. 43% of RLS-associated conditions have also been associated with systemic iron deficiency. The objective of this study was to review in the literature the relationship between iron metabolism and RLS. With an initial search using the keywords combination "Iron Metabolism OR Iron Deficiency AND Restless Legs Syndrome," 145 articles were screened, and 20 articles were selected. Few studies were found for this review in the period of 2001-2014, however, the correlation between RLS and iron was evident.

Keywords: Attention Deficit Hyperactivity Disorder; Iron Deficiency Anemia; Iron Genes; Pregnancy; Restless Legs Syndrome; Supplementation.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. García-Borreguero D., Williams A.M. Dopaminergic argumentation of restless legs syndrome. Sleep Med Rev. 2010;14:339–346. - PubMed
    1. Grote L., Leissner L., Hedner J., Usfberg J. A randomized, double-blind, placebo controlled, multi-center study of intravenous iron sucrose and placebo in the treatment of restless legs syndrome. Mov Disord. 2009;24:1445–1452. - PubMed
    1. Spolador T., Allis J.C., Pondé M.P. Treatment of restless legs syndrome. Revista Brasileira de Psiquiatria. 2006;28:308–315. - PubMed
    1. Oner P., Dirik E.B., Taner Y., Caykoylu A., Anlar O. Association between low serum ferritin and restless legs syndrome in patients with attention deficit hyperactivity disorder. Tohoku J Exp Med. 2007;213:269–276. - PubMed
    1. Weinstock L.B., Walters A.S., Paueksakon P. Restless legs syndrome – Theoretical roles of inflammatory and immune mechanisms. Sleep Med Rev. 2012;16:341–354. - PubMed