Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Jun;34(2):98-102.
doi: 10.1016/j.krcp.2015.03.001. Epub 2015 Mar 27.

Changes in serum magnesium concentration after use of a proton pump inhibitor in patients undergoing percutaneous coronary intervention

Sang-Ho Park  1 , Sun-Hyo Lee  1 , Ji-Sung Lee  2 , Won-Yong Shin  1 , Hyo-Wook Gil  1 , Jong-Oh Yang  1 , Eun-Young Lee  1 , Sae-Yong Hong  1
Affiliations

Changes in serum magnesium concentration after use of a proton pump inhibitor in patients undergoing percutaneous coronary intervention

Sang-Ho Park et al. Kidney Res Clin Pract. 2015 Jun.

Abstract

Background: Although cross-sectional studies have suggested a relationship between proton pump inhibitor (PPI) use and hypomagnesemia, no large-scale cohort study has been conducted to date. Here, we examined the changes in serum magnesium levels in response to PPI use. We hypothesized that PPI use might change the serum magnesium concentration.

Methods: Of the 2,892 patients hospitalized for percutaneous coronary intervention between January 2007 and May 2012, 1,076 patients with normal baseline (1.6-2.5 mg/dL) and follow-up serum magnesium concentrations were enrolled. These patients were divided into two groups: the PPI group and the control group.

Results: The mean follow-up period was 9.51 ± 2.94 months. The incidence of hypomagnesemia (< 1.6 mg/dL) was 0.4% (3/834) in the PPI group and 0.4% (1/242) in the control group (P = 0.904). The change in magnesium levels did not differ between the two groups, and this result was maintained in the analysis of covariance after adjusting for confounding factors (P = 0.381). Moreover, magnesium levels did not significantly differ between the long-term (duration of use ≥ 12 months, n = 71) and short-term PPI groups (duration of use < 12 months, n = 763), and the control group (n = 242; P = 0.620). The effect of PPI use on change in serum magnesium concentration was affected by the use of multiple diuretics (-0.01 ± 0.25 mg/dL; P = 0.025), although a single diuretic use with PPI did not alter the change in magnesium level (0.12 ± 0.27 mg/dL).

Conclusion: Changes in magnesium levels might be subtle after PPI use in patients with normal baseline magnesium values.

Keywords: Diuretics; Magnesium; Proton pump inhibitor.

PubMed Disclaimer

Figures

Figure 1
Figure 1
The flowchart illustrates the patients’ inclusion and exclusion in this study. PCI, percutaneous coronary intervention; PPI, proton pump inhibitor.
See this image and copyright information in PMC

References

    1. Flink EB. Magnesium deficiency. Etiology and clinical spectrum. Acta Med Scand Suppl. 1981;647:125–137. - PubMed
    1. Moore MJ, Flink EB. Magnesium deficiency as a cause of serious arrhythmias. Arch Intern Med. 1978;138:825–826. - PubMed
    1. Ray S, Delaney M, Muller AF. Proton pump inhibitors and acute interstitial nephritis. BMJ. 2010;341:c4412. - PubMed
    1. Sierra F, Suarez M, Rey M, Vela MF. Systematic review: proton pump inhibitor-associated acute interstitial nephritis. Aliment Pharmacol Ther. 2007;26:545–553. - PubMed
    1. Herzig SJ, Howell MD, Ngo LH, Marcantonio ER. Acid-suppressive medication use and the risk for hospital-acquired pneumonia. JAMA. 2009;301:2120–2128. - PubMed