Final Height and Associated Factors in Perinatally HIV-infected Asian Adolescents

doi:10.1097/INF.0000000000000961

. 2016 Feb;35(2):201-4.

doi: 10.1097/INF.0000000000000961.

Final Height and Associated Factors in Perinatally HIV-infected Asian Adolescents

Torsak Bunupuradah¹, Azar Kariminia, Linda Aurpibul, Kulkanya Chokephaibulkit, Rawiwan Hansudewechakul, Pagakrong Lumbiganon, Saphonn Vonthanak, Ung Vibol, Suneeta Saghayam, Revathy Nallusamy, Lam Van Nguyen, Nik Khairulddin N Yusoff, Annette H Sohn, Thanyawee Puthanakit; TREAT Asia Pediatric HIV Observational Database

Collaborators, Affiliations

Collaborators

TREAT Asia Pediatric HIV Observational Database:
C V Mean, V Saphonn, S Sarun, V Ung, M Pok, Y Kdan, B Chan, J Tucker, F J Zhang, N Kumarasamy, S Saghayam, E Chandrasekaran, D K Wati, L P P Atmikasari, I Y Malino, N Kurniati, D Muktiarti, S M Fong, M Thien, M Lim, F Daut, N K Nik Yusoff, P Mohamad, K A Razali, T J Mohamed, N F Abdul Rahman, N A D R Mohammed, R Nallusamy, K C Chan, V Sirisanthana, P Oberdorfer, L Aurpibul, T Sudjaritruk, R Hansudewechakul, S Denjanta, W Srisuk, A Kongphonoi, P Lumbiganon, P Kosalaraksa, P Tharnprisan, T Udomphanit, G Jourdain, T Bunupuradah, T Puthanakit, W Prasitsuebsai, W Chanthaweethip, K Chokephaibulkit, K Lapphra, W Phongsamart, S Sricharoenchai, K H Truong, Q T Du, C H Nguyen, V C Do, T M Ha, V T An, L V Nguyen, D T K Khu, A N Pham, L T Nguyen, O N Le, A H Sohn, N Durier, C Sethaputra, D A Cooper, M G Law, A Kariminia

Affiliation

¹ From the *HIV-NAT, the Thai Red Cross AIDS Research Centre, Bangkok, Thailand; †The Kirby Institute, University of New South Wales, Sydney, Australia; ‡Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand; §Department of Pediatrics, Siriraj Hospital, Mahidol University, Bangkok, Thailand; ¶Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand; ‖Division of Infectious Diseases, Department of Pediatrics, Khon Kaen University, Khon Kaen, Thailand; **Research Unit, National Centre for HIV/AIDS, Dermatology and STDs, Phnom Penh, Cambodia; ††Department of Public Health, University of Health Sciences, Phnom Penh, Cambodia; ‡‡Pediatric TB/HIV/AIDS Care Department, National Pediatric Hospital, Phnom Penh, Cambodia; §§YR Gaitonde Centre for AIDS Research and Education, Chennai, India; ¶¶Department of Pediatrics, Penang Hospital, Penang, Malaysia; ‖‖Infectious Disease Department, National Hospital of Pediatrics, Hanoi, Vietnam; ***Department of Pediatrics, Hospital Raja Perempuan Zainab II, Kelantan, Malaysia; †††TREAT Asia/amfAR, The Foundation for AIDS Research, Bangkok, Thailand; and ‡‡‡Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

PMID: 26484429
PMCID: PMC4712093
DOI: 10.1097/INF.0000000000000961

Final Height and Associated Factors in Perinatally HIV-infected Asian Adolescents

Torsak Bunupuradah et al. Pediatr Infect Dis J. 2016 Feb.

. 2016 Feb;35(2):201-4.

doi: 10.1097/INF.0000000000000961.

Authors

Collaborators

TREAT Asia Pediatric HIV Observational Database:
C V Mean, V Saphonn, S Sarun, V Ung, M Pok, Y Kdan, B Chan, J Tucker, F J Zhang, N Kumarasamy, S Saghayam, E Chandrasekaran, D K Wati, L P P Atmikasari, I Y Malino, N Kurniati, D Muktiarti, S M Fong, M Thien, M Lim, F Daut, N K Nik Yusoff, P Mohamad, K A Razali, T J Mohamed, N F Abdul Rahman, N A D R Mohammed, R Nallusamy, K C Chan, V Sirisanthana, P Oberdorfer, L Aurpibul, T Sudjaritruk, R Hansudewechakul, S Denjanta, W Srisuk, A Kongphonoi, P Lumbiganon, P Kosalaraksa, P Tharnprisan, T Udomphanit, G Jourdain, T Bunupuradah, T Puthanakit, W Prasitsuebsai, W Chanthaweethip, K Chokephaibulkit, K Lapphra, W Phongsamart, S Sricharoenchai, K H Truong, Q T Du, C H Nguyen, V C Do, T M Ha, V T An, L V Nguyen, D T K Khu, A N Pham, L T Nguyen, O N Le, A H Sohn, N Durier, C Sethaputra, D A Cooper, M G Law, A Kariminia

Affiliation

¹ From the *HIV-NAT, the Thai Red Cross AIDS Research Centre, Bangkok, Thailand; †The Kirby Institute, University of New South Wales, Sydney, Australia; ‡Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand; §Department of Pediatrics, Siriraj Hospital, Mahidol University, Bangkok, Thailand; ¶Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand; ‖Division of Infectious Diseases, Department of Pediatrics, Khon Kaen University, Khon Kaen, Thailand; **Research Unit, National Centre for HIV/AIDS, Dermatology and STDs, Phnom Penh, Cambodia; ††Department of Public Health, University of Health Sciences, Phnom Penh, Cambodia; ‡‡Pediatric TB/HIV/AIDS Care Department, National Pediatric Hospital, Phnom Penh, Cambodia; §§YR Gaitonde Centre for AIDS Research and Education, Chennai, India; ¶¶Department of Pediatrics, Penang Hospital, Penang, Malaysia; ‖‖Infectious Disease Department, National Hospital of Pediatrics, Hanoi, Vietnam; ***Department of Pediatrics, Hospital Raja Perempuan Zainab II, Kelantan, Malaysia; †††TREAT Asia/amfAR, The Foundation for AIDS Research, Bangkok, Thailand; and ‡‡‡Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

PMID: 26484429
PMCID: PMC4712093
DOI: 10.1097/INF.0000000000000961

Abstract

We analyzed final height of 273 perinatally HIV-infected Asian adolescents older than 18 years at their last clinic visit. By the World Health Organization child growth reference, 30% were stunted, but by the Thai child growth reference, 19% were stunted. Half of those who were stunted at antiretroviral therapy initiation remained stunted over time. Being male and having a low baseline height-for-age Z score of less than -1.0 were associated with low final height Z score.

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Conflict of interest statement

Disclosures: The authors have no conflicts of interest or funding to disclose

Figures

**Figure 1**
Stunting outcomes by WHO child growth reference standards Final height was defined as height at the age of 18 years. Stunting was defined as height-for-age z-score of <−2.0 (5)

See this image and copyright information in PMC

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References

1. Newell ML, Borja MC, Peckham C. Height, weight, and growth in children born to mothers with HIV-1 infection in Europe. Pediatrics. 2003 Jan;111(1):e52–60. - PubMed
1. Stagi S, Galli L, Cecchi C, Chiappini E, Losi S, Gattinara CG, et al. Final height in patients perinatally infected with the human immunodeficiency virus. Horm Res Paediatr. 2010;74(3):165–71. - PubMed
1. Kessler M, Kaul A, Santos-Malave C, Borkowsky W, Kessler J, Shah B. Growth patterns in pubertal HIV-infected adolescents and their correlation with cytokines, IGF-1, IGFBP-1, and IGFBP-3. J Pediatr Endocrinol Metab. 2013;26(7–8):639–44. - PMC - PubMed
1. DiMeglio LA, Wang J, Siberry GK, Miller TL, Geffner ME, Hazra R, et al. Bone mineral density in children and adolescents with perinatal HIV infection. AIDS (London, England) 2013 Jan 14;27(2):211–20. - PMC - PubMed
1. Buonora S, Nogueira S, Pone MV, Aloe M, Oliveira RH, Hofer C. Growth parameters in HIV-vertically-infected adolescents on antiretroviral therapy in Rio de Janeiro, Brazil. Annals of tropical paediatrics. 2008 Mar;28(1):59–64. - PubMed

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[1] Newell ML, Borja MC, Peckham C. Height, weight, and growth in children born to mothers with HIV-1 infection in Europe. Pediatrics. 2003 Jan;111(1):e52–60. - PubMed

[2] Newell ML, Borja MC, Peckham C. Height, weight, and growth in children born to mothers with HIV-1 infection in Europe. Pediatrics. 2003 Jan;111(1):e52–60. - PubMed

[3] Stagi S, Galli L, Cecchi C, Chiappini E, Losi S, Gattinara CG, et al. Final height in patients perinatally infected with the human immunodeficiency virus. Horm Res Paediatr. 2010;74(3):165–71. - PubMed

[4] Stagi S, Galli L, Cecchi C, Chiappini E, Losi S, Gattinara CG, et al. Final height in patients perinatally infected with the human immunodeficiency virus. Horm Res Paediatr. 2010;74(3):165–71. - PubMed

[5] Kessler M, Kaul A, Santos-Malave C, Borkowsky W, Kessler J, Shah B. Growth patterns in pubertal HIV-infected adolescents and their correlation with cytokines, IGF-1, IGFBP-1, and IGFBP-3. J Pediatr Endocrinol Metab. 2013;26(7–8):639–44. - PMC - PubMed

[6] Kessler M, Kaul A, Santos-Malave C, Borkowsky W, Kessler J, Shah B. Growth patterns in pubertal HIV-infected adolescents and their correlation with cytokines, IGF-1, IGFBP-1, and IGFBP-3. J Pediatr Endocrinol Metab. 2013;26(7–8):639–44. - PMC - PubMed

[7] DiMeglio LA, Wang J, Siberry GK, Miller TL, Geffner ME, Hazra R, et al. Bone mineral density in children and adolescents with perinatal HIV infection. AIDS (London, England) 2013 Jan 14;27(2):211–20. - PMC - PubMed

[8] DiMeglio LA, Wang J, Siberry GK, Miller TL, Geffner ME, Hazra R, et al. Bone mineral density in children and adolescents with perinatal HIV infection. AIDS (London, England) 2013 Jan 14;27(2):211–20. - PMC - PubMed

[9] Buonora S, Nogueira S, Pone MV, Aloe M, Oliveira RH, Hofer C. Growth parameters in HIV-vertically-infected adolescents on antiretroviral therapy in Rio de Janeiro, Brazil. Annals of tropical paediatrics. 2008 Mar;28(1):59–64. - PubMed

[10] Buonora S, Nogueira S, Pone MV, Aloe M, Oliveira RH, Hofer C. Growth parameters in HIV-vertically-infected adolescents on antiretroviral therapy in Rio de Janeiro, Brazil. Annals of tropical paediatrics. 2008 Mar;28(1):59–64. - PubMed

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Final Height and Associated Factors in Perinatally HIV-infected Asian Adolescents

Collaborators

Affiliation

Final Height and Associated Factors in Perinatally HIV-infected Asian Adolescents

Authors

Collaborators

Affiliation

Abstract

Conflict of interest statement

Figures

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Cited by

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Medical