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. 2015 Oct 16;63(2):163-8.
doi: 10.3233/CH-152016.

Lipid peroxidation and nitric oxide metabolites in a group of subjects with obstructive sleep apnea syndrome

Gregorio Caimi, Rosalia Lo Presti, Maria Montana, Caterina Urso, Baldassare Canino, Eugenia Hopps

Lipid peroxidation and nitric oxide metabolites in a group of subjects with obstructive sleep apnea syndrome

Gregorio Caimi et al. Clin Hemorheol Microcirc. .

Abstract

It is known that in OSAS the plasma lipid peroxidation has an opposite behavior in comparison with nitric oxide metabolites. In the re-examination of our survey of OSAS subjects we calculated the ratio between thiobarbituric acid reactive substances (TBARS) and nitric oxide metabolites (NOx) in relation to OSAS severity. The study has regarded 48 OSAS subjects subdivided in two subgroups according to the apnea/hypopnea index - AHI- (Low = 21 subjects with AHI <30 and High = 27 subjects with AHI >30). From the obtained data it is evident that the TBARS/NOx ratio is significantly higher in the H subgroup compared to L subgroup as well as this ratio is reduced in L subgroup in comparison with the whole group of OSAS subjects. In the entire group of OSAS subjects the TBARS/NOx ratio results positively correlated with AHI and ODI and inversely correlated with mSO2.

Keywords: Lipid peroxidation; nitric oxide metabolites; obstructive sleep apnea syndrome.

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