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Review
. 2016:880:293-308.
doi: 10.1007/978-3-319-22536-4_16.

Microbubble-Assisted Ultrasound for Drug Delivery in the Brain and Central Nervous System

Alison Burgess  1 , Kullervo Hynynen  2   3
Affiliations
Review

Microbubble-Assisted Ultrasound for Drug Delivery in the Brain and Central Nervous System

Alison Burgess et al. Adv Exp Med Biol. 2016.

Abstract

The blood-brain barrier is a serious impediment to the delivery of pharmaceutical treatments for brain diseases, including cancer, neurodegenerative and neuropsychatric diseases. Focused ultrasound, when combined with microbubbles, has emerged as an effective method to transiently and locally open the blood-brain barrier to promote drug delivery to the brain. Focused ultrasound has been used to successfully deliver a wide variety of therapeutic agents to pre-clinical disease models. The requirement for clinical translation of focused ultrasound technology is considered.

Keywords: Alzheimer’s disease; Blood-brain barrier; Drug delivery; Focused ultrasound; Glioblastoma.

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