Finding the Therapeutic Sweet Spot: Using Naturally Occurring Human Variants to Inform Drug Design

Affiliations

¹ From the Department of Clinical Biochemistry, PathWest Laboratory Medicine, Royal Perth Hospital, Perth, Western Australia, Australia (J.R.B.); and School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia (J.R.B.); and Department of Medicine and Robarts Research Institute, Schulich School of Medicine, Western University, London, Ontario, Canada (R.A.H.).
² From the Department of Clinical Biochemistry, PathWest Laboratory Medicine, Royal Perth Hospital, Perth, Western Australia, Australia (J.R.B.); and School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia (J.R.B.); and Department of Medicine and Robarts Research Institute, Schulich School of Medicine, Western University, London, Ontario, Canada (R.A.H.). hegele@robarts.ca.

Editorial

John R Burnett et al. Circ Cardiovasc Genet. 2015 Oct.

. 2015 Oct;8(5):637-9.

doi: 10.1161/CIRCGENETICS.115.001219.

¹ From the Department of Clinical Biochemistry, PathWest Laboratory Medicine, Royal Perth Hospital, Perth, Western Australia, Australia (J.R.B.); and School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia (J.R.B.); and Department of Medicine and Robarts Research Institute, Schulich School of Medicine, Western University, London, Ontario, Canada (R.A.H.).
² From the Department of Clinical Biochemistry, PathWest Laboratory Medicine, Royal Perth Hospital, Perth, Western Australia, Australia (J.R.B.); and School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia (J.R.B.); and Department of Medicine and Robarts Research Institute, Schulich School of Medicine, Western University, London, Ontario, Canada (R.A.H.). hegele@robarts.ca.

No abstract available

Keywords: Editorials; apolipoproteins B; cholesterol, LDL; genetics; humans; mutation.

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