Finding the Therapeutic Sweet Spot: Using Naturally Occurring Human Variants to Inform Drug Design

Affiliations

¹ From the Department of Clinical Biochemistry, PathWest Laboratory Medicine, Royal Perth Hospital, Perth, Western Australia, Australia (J.R.B.); and School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia (J.R.B.); and Department of Medicine and Robarts Research Institute, Schulich School of Medicine, Western University, London, Ontario, Canada (R.A.H.).
² From the Department of Clinical Biochemistry, PathWest Laboratory Medicine, Royal Perth Hospital, Perth, Western Australia, Australia (J.R.B.); and School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia (J.R.B.); and Department of Medicine and Robarts Research Institute, Schulich School of Medicine, Western University, London, Ontario, Canada (R.A.H.). hegele@robarts.ca.

Editorial

John R Burnett et al. Circ Cardiovasc Genet. 2015 Oct.

. 2015 Oct;8(5):637-9.

doi: 10.1161/CIRCGENETICS.115.001219.

¹ From the Department of Clinical Biochemistry, PathWest Laboratory Medicine, Royal Perth Hospital, Perth, Western Australia, Australia (J.R.B.); and School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia (J.R.B.); and Department of Medicine and Robarts Research Institute, Schulich School of Medicine, Western University, London, Ontario, Canada (R.A.H.).
² From the Department of Clinical Biochemistry, PathWest Laboratory Medicine, Royal Perth Hospital, Perth, Western Australia, Australia (J.R.B.); and School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia (J.R.B.); and Department of Medicine and Robarts Research Institute, Schulich School of Medicine, Western University, London, Ontario, Canada (R.A.H.). hegele@robarts.ca.

No abstract available

Keywords: Editorials; apolipoproteins B; cholesterol, LDL; genetics; humans; mutation.

Comment on

Novel Abetalipoproteinemia Missense Mutation Highlights the Importance of the N-Terminal β-Barrel in Microsomal Triglyceride Transfer Protein Function.
Walsh MT, Iqbal J, Josekutty J, Soh J, Di Leo E, Özaydin E, Gündüz M, Tarugi P, Hussain MM. Walsh MT, et al. Circ Cardiovasc Genet. 2015 Oct;8(5):677-87. doi: 10.1161/CIRCGENETICS.115.001106. Epub 2015 Jul 29. Circ Cardiovasc Genet. 2015. PMID: 26224785 Free PMC article.