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. 2015 Oct;6(5):492-7.
doi: 10.3978/j.issn.2078-6891.2015.049.

Establishing the link between hepatitis B virus infection and colorectal adenoma

Brijesh B Patel  1 , Seth Lipka  1 , Huafeng Shen  1 , Ashley H Davis-Yadley  1 , Prakash Viswanathan  1
Affiliations

Establishing the link between hepatitis B virus infection and colorectal adenoma

Brijesh B Patel et al. J Gastrointest Oncol. 2015 Oct.

Abstract

Background: Chronic hepatitis B (CHB) infection has been associated with malignancy, most notably hepatocellular carcinoma. Previous research has shown that hepatitis C is associated with increased colorectal adenomas and neoplasia. Currently, there are no studies on the association of CHB and colorectal adenomas. We aimed to identify a possible link between CHB and colorectal adenoma.

Methods: A retrospective chart review was performed on 588 consecutive patients undergoing screening or diagnostic colonoscopy that were previously screened or diagnosed with hepatitis B. Comparisons between categorical variables were analyzed with Chi Square test and t-test for continuous variables. Unconditional logistic regression was used to generate age-, gender-and race-adjusted odds ratios and their 95% confidence intervals (CI) comparing medication users with non-users. Statistical analyses were performed with SAS 9.3 software.

Results: A total of 487 patients were analyzed in the control group vs. 71 in the hepatitis B group. The adenoma detection rate was 23.9% in hepatitis B vs. 15.9% in the non-hepatitis B group for all cause colonoscopy; however this did not reach statistical significance. There was a significantly higher number of adenomas present in the distal colon compared to control (OR =2.16; 95% CI, 1.06-4.43; P=0.04). There were no significant findings between hepatitis B infection with size, multiplicity or presence of proximal adenomas. There was a significant difference noted in regards to smoking history, BMI and age between two groups.

Conclusions: Although the adenoma detection rate was higher in hepatitis B population vs. the non-hepatitis B group this did not reach statistical significance. However, we did find an association between CHB infection and the presence of distal colorectal adenomas. Larger prospective studies are needed to strengthen our findings along with future studies examining hepatitis B virus (HBV) and mechanisms inducing colorectal carcinogenesis.

Keywords: Colon cancer; colorectal adenomas; hepatitis B.

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

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References

    1. Simonetti RG, Cammà C, Fiorello F, et al. Hepatitis C virus infection as a risk factor for hepatocellular carcinoma in patients with cirrhosis. A case-control study. Ann Intern Med 1992;116:97-102. - PubMed
    1. Kalaitzakis E, Gunnarsdottir SA, Josefsson A, et al. Increased risk for malignant neoplasms among patients with cirrhosis. Clin Gastroenterol Hepatol 2011;9:168-74. - PubMed
    1. Fattovich G, Pantalena M, Zagni I, et al. Effect of hepatitis B and C virus infections on the natural history of compensated cirrhosis: a cohort study of 297 patients. Am J Gastroenterol 2002;97:2886-95. - PubMed
    1. Hepatitis B Foundation. Hepatitis B Statistics. 2014. Accessed on May 25th, 2014. Available online: http://www.hepb.org/hepb/statistics.htm
    1. Lee WM. Hepatitis B virus infection. N Engl J Med 1997;337:1733-45. - PubMed