Littoral cell angioma: A case report

Abstract

Primary splenic lesions are rare entities among which littoral cell angioma (LCA) is a recently described, uncommon vascular lesion that is unique to the spleen. It has heretofore been described primarily in pathologic series and has been found mostly to behave as a benign entity. A few reports of malignant variants have been reported. We present a case report of a solitary LCA discovered after splenectomy for an incidentally discovered splenic lesion, along with a literature review.

Keywords: Littoral cell angioma; Splenic tumor.

Figure 1

Computed tomography abdomen and pelvis, axial view of hypodense splenic lesion.

Figure 2

High power view of the tumor demonstrates tall columnar endothelial cells that line the cyst-like spaces. These cells show no cytologic, nuclear atypia or mitotic figures (H and E stain, × 400).

Figure 3

Low power view of the well-demarcated tumor with uninvolved spleen. The tumor has anastomosing vascular channels and cyst-like hemorrhagic spaces.

Figure 4

Endothelial cells lining the cyst-like spaces are immunoreactive. A: CD68 (CD68 stain, × 100); B: Histiocytic marker lysozyme (lysozyme stain, × 400); C: Endothelial marker CD34 and the histocytoid cells are negative for CD34 (CD34 stain, × 400); D: Endothelial marker CD31 (CD31 stain, × 400).