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Case Reports
. 2015 Oct 16;3(10):894-9.
doi: 10.12998/wjcc.v3.i10.894.

Littoral cell angioma: A case report

Amanda Bailey  1 , Jeffrey Vos  1 , Jon Cardinal  1
Affiliations
Case Reports

Littoral cell angioma: A case report

Amanda Bailey et al. World J Clin Cases. .

Abstract

Primary splenic lesions are rare entities among which littoral cell angioma (LCA) is a recently described, uncommon vascular lesion that is unique to the spleen. It has heretofore been described primarily in pathologic series and has been found mostly to behave as a benign entity. A few reports of malignant variants have been reported. We present a case report of a solitary LCA discovered after splenectomy for an incidentally discovered splenic lesion, along with a literature review.

Keywords: Littoral cell angioma; Splenic tumor.

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Figures

Figure 1
Figure 1
Computed tomography abdomen and pelvis, axial view of hypodense splenic lesion.
Figure 2
Figure 2
High power view of the tumor demonstrates tall columnar endothelial cells that line the cyst-like spaces. These cells show no cytologic, nuclear atypia or mitotic figures (H and E stain, × 400).
Figure 3
Figure 3
Low power view of the well-demarcated tumor with uninvolved spleen. The tumor has anastomosing vascular channels and cyst-like hemorrhagic spaces.
Figure 4
Figure 4
Endothelial cells lining the cyst-like spaces are immunoreactive. A: CD68 (CD68 stain, × 100); B: Histiocytic marker lysozyme (lysozyme stain, × 400); C: Endothelial marker CD34 and the histocytoid cells are negative for CD34 (CD34 stain, × 400); D: Endothelial marker CD31 (CD31 stain, × 400).
See this image and copyright information in PMC

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