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Clinical Trial
. 1989 Apr;146(4):513-6.
doi: 10.1176/ajp.146.4.513.

A controlled trial of desipramine in 18 men with posttraumatic stress disorder

C Reist  1 , C D Kauffmann, R J Haier, C Sangdahl, E M DeMet, A Chicz-DeMet, J N Nelson
Affiliations
Clinical Trial

A controlled trial of desipramine in 18 men with posttraumatic stress disorder

C Reist et al. Am J Psychiatry. 1989 Apr.

Abstract

Eighteen male U.S. veterans meeting DSM-III criteria for posttraumatic stress disorder (PTSD) completed a 4-week double-blind, crossover study comparing administration of 200 mg/day of desipramine with placebo. Response was measured by using the Beck Depression Inventory, the Hamilton Rating Scale for Depression, the Hamilton Rating Scale for Anxiety, and the Impact of Event Scale. Overall, the only apparent response to desipramine was in some symptoms of depression; there were no changes in anxiety and other PTSD symptoms.

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Comment in

  • Antidepressants in the treatment of PTSD.
    Frank JB, Kosten TR, Giller EL Jr. Frank JB, et al. Am J Psychiatry. 1990 Feb;147(2):260. doi: 10.1176/ajp.147.2.260a. Am J Psychiatry. 1990. PMID: 2301678 No abstract available.
  • Measuring results of treatment of PTSD.
    Kudler HS, Davidson JR, Stein R, Erickson L. Kudler HS, et al. Am J Psychiatry. 1989 Dec;146(12):1645-6. doi: 10.1176/ajp.146.12.aj146121645. Am J Psychiatry. 1989. PMID: 2686479 Clinical Trial. No abstract available.

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