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Comment
. 2015 Oct 20;43(4):620-2.
doi: 10.1016/j.immuni.2015.10.001.

Gut-Busters: IL-17 Ain't Afraid of No IL-23

Natasha Whibley  1 , Sarah L Gaffen  2
Affiliations
Comment

Gut-Busters: IL-17 Ain't Afraid of No IL-23

Natasha Whibley et al. Immunity. .

Abstract

Interleukin-23 (IL-23) is considered a critical regulator of IL-17 in lymphocytes. Whereas antibodies targeting IL-23 ameliorate colitis, IL-17 neutralization exacerbates disease. In this issue, Cua and colleagues and Maxwell and colleagues show that IL-17 maintains intestinal barrier integrity, helping explain this dichotomy (Lee et al., 2015; Maxwell et al., 2015).

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References

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