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Comment
. 2015 Oct 20;43(4):631-3.
doi: 10.1016/j.immuni.2015.10.004.

Tumor Microenvironment and Immunotherapy: The Whole Picture Is Better Than a Glimpse

Sarah E Church  1 , Jérôme Galon  2
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Free article
Comment

Tumor Microenvironment and Immunotherapy: The Whole Picture Is Better Than a Glimpse

Sarah E Church et al. Immunity. .
Free article

Abstract

Predicting cancer patients' response to therapy is essential for curing disease and improving quality of life. Garraway and colleagues demonstrate that the frequency and number of neoantigens, non-synonymous mutations, and adaptive immune genes, but not the assessment of individual recurrent neoantigens or mutations, predicts patient responses to immunotherapy.

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  • Genomic correlates of response to CTLA-4 blockade in metastatic melanoma.
    Van Allen EM, Miao D, Schilling B, Shukla SA, Blank C, Zimmer L, Sucker A, Hillen U, Foppen MHG, Goldinger SM, Utikal J, Hassel JC, Weide B, Kaehler KC, Loquai C, Mohr P, Gutzmer R, Dummer R, Gabriel S, Wu CJ, Schadendorf D, Garraway LA. Van Allen EM, et al. Science. 2015 Oct 9;350(6257):207-211. doi: 10.1126/science.aad0095. Epub 2015 Sep 10. Science. 2015. PMID: 26359337 Free PMC article.

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