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. 2016 Jan 4;55(1):264-7.
doi: 10.1002/anie.201507801. Epub 2015 Oct 22.

Ruthenium Oxidase Catalysis for Site-Selective C-H Alkenylations with Ambient O2 as the Sole Oxidant

Alexander Bechtoldt  1 , Carina Tirler  1 , Keshav Raghuvanshi  1 , Svenja Warratz  1 , Christoph Kornhaaß  1 , Lutz Ackermann  2
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Ruthenium Oxidase Catalysis for Site-Selective C-H Alkenylations with Ambient O2 as the Sole Oxidant

Alexander Bechtoldt et al. Angew Chem Int Ed Engl. .

Abstract

Ruthenium(II) oxidase catalysis by direct dioxygen-coupled turnover enabled step-economical oxidative C-H alkenylation reactions at ambient pressure. Versatile ruthenium(II) biscarboxylate catalysts displayed ample substrate scope and proved applicable to weakly coordinating and removable directing groups. The twofold C-H functionalization strategy was characterized by exceedingly mild reaction conditions as well as excellent positional selectivity.

Keywords: CH activation; alkenes; oxidation; ruthenium; synthetic methods.

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