Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1989 Mar 31;159(3):1435-40.
doi: 10.1016/0006-291x(89)92270-5.

Transforming growth factor-beta stimulates the expression of endothelin mRNA by vascular endothelial cells

H Kurihara  1 , M Yoshizumi, T Sugiyama, F Takaku, M Yanagisawa, T Masaki, M Hamaoki, H Kato, Y Yazaki
Affiliations

Transforming growth factor-beta stimulates the expression of endothelin mRNA by vascular endothelial cells

H Kurihara et al. Biochem Biophys Res Commun. .

Abstract

Endothelin is a potent vasoconstrictor peptide produced by vascular endothelial cells. Incubation of the serum-deprived confluent porcine aortic endothelial cells with 10-300 pM TGF-beta 1, resulted in a several fold increase in endothelin mRNA levels with a peak time of 2 h. An enzyme-linked immunosorbent assay revealed that the levels of endothelin in endothelial cell conditioned media was also increased by TGF-beta 1. These results suggest that TGF-beta 1, secreted by activated platelets, is involved not only in wound healing, but in the regulation of local vascular tone by stimulating endothelin production in the endothelial cells.

PubMed Disclaimer

Publication types

LinkOut - more resources