B cells assume the command

Affiliations

¹ Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University of Mainz, 55131 Mainz, Germany. waisman@uni-mainz.de.
² Department of Neurology, Klinikum rechts der Isar, Technische Universitaet Muenchen, 81675 Munich, Germany. Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.

Comment

Ari Waisman et al. Sci Transl Med. 2015.

. 2015 Oct 21;7(310):310fs42.

doi: 10.1126/scitranslmed.aad2740.

¹ Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University of Mainz, 55131 Mainz, Germany. waisman@uni-mainz.de.
² Department of Neurology, Klinikum rechts der Isar, Technische Universitaet Muenchen, 81675 Munich, Germany. Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.

Abstract

A proinflammatory B cell cytokine activates autoimmunity, and B cell depletion treats multiple sclerosis (Li et al., this issue).

Proinflammatory GM-CSF-producing B cells in multiple sclerosis and B cell depletion therapy.
Li R, Rezk A, Miyazaki Y, Hilgenberg E, Touil H, Shen P, Moore CS, Michel L, Althekair F, Rajasekharan S, Gommerman JL, Prat A, Fillatreau S, Bar-Or A; Canadian B cells in MS Team. Li R, et al. Sci Transl Med. 2015 Oct 21;7(310):310ra166. doi: 10.1126/scitranslmed.aab4176. Sci Transl Med. 2015. PMID: 26491076