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. 2016 Jan;54(1):168-71.
doi: 10.1128/JCM.02478-15. Epub 2015 Oct 21.

First Detection of TR34 L98H and TR46 Y121F T289A Cyp51 Mutations in Aspergillus fumigatus Isolates in the United States

Nathan P Wiederhold  1 , Veronica Garcia Gil  2 , Felipe Gutierrez  3 , Jonathan R Lindner  4 , Mohammad T Albataineh  4 , Dora I McCarthy  4 , Carmita Sanders  4 , Hongxin Fan  4 , Annette W Fothergill  4 , Deanna A Sutton  4
Affiliations

First Detection of TR34 L98H and TR46 Y121F T289A Cyp51 Mutations in Aspergillus fumigatus Isolates in the United States

Nathan P Wiederhold et al. J Clin Microbiol. 2016 Jan.

Abstract

Azole resistance in Aspergillus fumigatus is an increasing problem. The TR34 L98H and TR46 Y121F T289A mutations that can occur in patients without previous azole exposure have been reported in Europe, Asia, the Middle East, Africa, and Australia. Here, we report the detection of both the TR34 L98H and TR46 Y121F T289A mutations in confirmed A. fumigatus isolates collected in institutions in the United States. These mutations, other mutations known to cause azole resistance, and azole MICs are reported here.

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Figures

FIG 1
FIG 1
Shown are the MICs for voriconazole versus isavuconazole (A), voriconazole versus posaconazole (B), and posaconazole versus isavuconazole (C). All MICs were read as 100% inhibition of growth after 48 h of incubation at 35°C. MICs of >16 μg/ml were plotted at 32 μg/ml.
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