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. 2015:2015:232048.
doi: 10.1155/2015/232048. Epub 2015 Sep 30.

The Relation between eNOS -786 C/T, 4 a/b, MMP-13 rs640198 G/T, Eotaxin 426 C/T, -384 A/G, and 67 G/A Polymorphisms and Long-Term Outcome in Patients with Coronary Artery Disease

Vladimír Kincl  1 , Jan Máchal  2 , Adéla Drozdová  1 , Roman Panovský  1 , Anna Vašků  3
Affiliations

The Relation between eNOS -786 C/T, 4 a/b, MMP-13 rs640198 G/T, Eotaxin 426 C/T, -384 A/G, and 67 G/A Polymorphisms and Long-Term Outcome in Patients with Coronary Artery Disease

Vladimír Kincl et al. Dis Markers. 2015.

Abstract

Aim: The purpose of this study is to determine the association between eotaxin 426 C/T, -384 A/G, 67 G/A, eNOS -786 T/C, 4 a/b, and MMP-13 rs640198 G/T and prognosis of patients with known CAD.

Methods: From total of 1161 patients referred to coronary angiography, 532 patients with angiographically confirmed CAD were selected. Their long-term outcome was followed up using hospital database. Subsequent events were assessed in this study: death or combined endpoint-myocardial infarction, unstable angina pectoris, revascularization, heart failure hospitalization, and cardioverter-defibrillator implantation.

Results: The multivariate Cox regression model identified age, smoking, and 3-vessel disease as significant predictors of all-cause death. Further analysis showed that eotaxin 67 G/A (GA + AA versus GG) and eotaxin -384 A/G (GG versus GA + AA) were significant independent prognostic factors when added into the model: HR (95% CI) 2.81 (1.35-5.85), p = 0.006; HR (95% CI) 2.63 (1.19-5.83), p = 0.017; eotaxin -384 A/G was significantly associated with the event-free survival, but it did not provide the prognostic information above the effect of two- or three-vessel disease.

Conclusion: The A allele in eotaxin 67 G/A polymorphism is associated with worse survival in CAD patients.

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Figures

Figure 1
Figure 1
Kaplan-Meier analysis of survival in patients cohort.
Figure 2
Figure 2
Kaplan-Meier analysis of event-free survival in patients cohort.
Figure 3
Figure 3
Kaplan-Meier analysis of survival by 67 G/A genotype.
See this image and copyright information in PMC

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