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Case Reports
. 1989 Mar;58(3):151-3.
doi: 10.1007/BF00320436.

Identification of the target platelet glycoprotein in autoimmune thrombocytopenia occurring after allogeneic bone marrow transplantation

H Benda  1 , S Panzer, V Kiefel, C Mannhalter, W Hinterberger, K Lechner, C Mueller-Eckhardt
Affiliations
Case Reports

Identification of the target platelet glycoprotein in autoimmune thrombocytopenia occurring after allogeneic bone marrow transplantation

H Benda et al. Blut. 1989 Mar.

Abstract

We report the case of a patient who developed autoimmune thrombocytopenia after allogeneic bone marrow transplantation from her HLA-identical sister. An IgG autoantibody was detected that bound to the platelet glycoprotein IIb/IIIa and to the HLA class I proteins. Immunoprecipitation studies with radiolabeled platelets revealed additional antibody binding sites on proteins of 214 kDa molecular weight under nonreduced conditions and 65 and 56 kDa molecular weight under reduced conditions.

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