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. 2015 Oct 22;6(10):e1937.
doi: 10.1038/cddis.2015.303.

Discovering in vitro spermatogenesis stimulating factors

J Chaudhary  1 , F K Hamra  1
Affiliations

Discovering in vitro spermatogenesis stimulating factors

J Chaudhary et al. Cell Death Dis. .
No abstract available

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Figures

Figure 1
Figure 1
In a new issue of Cell Death and Discovery, Chapman et al. report alternate growth factor pathways activated by NRG1 and KITL that are necessary for retinoic acid-induced syncytial growth of rat spermatozoan progenitors in vitro. As illustrated, FGF2 and GDNF maintain undifferentiated spermatogonial stem and progenitor cells in culture on laminin. Retinoic acid acts in the germline to drive transformation of undifferentiated spermatogonia into nascent differentiating spermatogonia. Polypeptide growth factors NRG1 and KITL are required for survival of differentiating spermatogonia on laminin without somatic cells. The defined cultures provide long-sought-after, soma-free platforms to study spermatogonial differentiation, and to discover additional spermatogenic factors for stimulating spermatogonia to undergo meiosis
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References

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