Review
doi: 10.1007/BF00205231.
Intratumour factors influencing the access of antibody to tumour cells
Affiliations
- PMID: 2649244
- PMCID: PMC11038556
- DOI: 10.1007/BF00205231
Item in Clipboard
Review
Intratumour factors influencing the access of antibody to tumour cells
Cancer Immunol Immunother.
1989.
Abstract
The histological structure and biochemical composition of human tumours is very varied, as is the structure of the microvascular network. It can be expected, therefore, that the extravasation, diffusion and convection of macromolecules will vary between tumours - and also between areas in the same tumour. The major factors influencing the intratumour distribution of injected antibody are reviewed and an attempt made to identify the tumour types in which therapeutic antibody, with or without a cytotoxin, will distribute most effectively.
Similar articles
-
Intratumour therapy of solid tumours with ricin-antibody conjugates.Immunol Cell Biol. 1989 Apr;67 ( Pt 2):89-99. doi: 10.1038/icb.1989.13. Immunol Cell Biol. 1989. PMID: 2786496
-
Transport of fluid and macromolecules in tumors. IV. A microscopic model of the perivascular distribution.Microvasc Res. 1991 Mar;41(2):252-72. doi: 10.1016/0026-2862(91)90026-8. Microvasc Res. 1991. PMID: 2051960
-
Pharmacokinetic considerations on monoclonal antibodies.Prog Clin Biol Res. 1989;288:429-38. Prog Clin Biol Res. 1989. PMID: 2654958 Review. No abstract available.
-
Vascular targeting--a new approach to the therapy of solid tumors.Pharmacol Ther. 1994 Oct;64(1):155-74. doi: 10.1016/0163-7258(94)90037-x. Pharmacol Ther. 1994. PMID: 7846113 Review.
-
[Angiogenin-induced angiogenesis as a target in the therapy of tumors].Eksp Klin Farmakol. 1998 Sep-Oct;61(5):81-4. Eksp Klin Farmakol. 1998. PMID: 9854643 Review. Russian. No abstract available.
Cited by
-
Multi-centre immunoscintigraphic study using indium-111-labelled CEA-specific and/or 19-9 monoclonal antibody F(ab')2 fragments.Eur J Nucl Med. 1990;17(5):223-9. doi: 10.1007/BF00812361. Eur J Nucl Med. 1990. PMID: 2083556 Clinical Trial.
-
Monoclonal antibody accumulation in experimental and spontaneous lung metastases of human malignant melanoma in rodents.J Cancer Res Clin Oncol. 1993;119(6):342-5. doi: 10.1007/BF01208842. J Cancer Res Clin Oncol. 1993. PMID: 8449971 Free PMC article.
-
Diffusion of an anti-transferrin receptor antibody in cultured murine melanoma cell layers.Pharm Res. 1995 Dec;12(12):1907-16. doi: 10.1023/a:1016424321378. Pharm Res. 1995. PMID: 8786965
-
Factors influencing variability of localisation of antibodies to carcinoembryonic antigen (CEA) in patients with colorectal carcinoma--implications for radioimmunotherapy.Br J Cancer. 1992 Jun;65(6):825-31. doi: 10.1038/bjc.1992.176. Br J Cancer. 1992. PMID: 1616854 Free PMC article.
-
Radioimmunotargeting of human tumour cells in immunocompetent animals.Br J Cancer. 1990 Oct;62(4):573-8. doi: 10.1038/bjc.1990.332. Br J Cancer. 1990. PMID: 2223574 Free PMC article.
References
-
- Bakay L. The extracellular space in brain tumors. I. Morphological considerations. Brain. 1970;93:693. - PubMed
-
- Baldwin RW. Monoclonal antibody targeting of anticancer agents: Mühlbock memorial lecture. Eur J Clin Oncol. 1985;21:1281. - PubMed
-
- Ballou B, Reiland J, Levine G, Knowles B, Hakala TR. Tumor location using F(ab′)2μ from a monoclonal IgM antibody: pharmacokinetics. J Nucl Med. 1985;26:283. - PubMed
-
- Begent RHJ, Keep PA, Green AJ, Searle F, Bagshawe KD, Jewkes RF, Jones BE, Barratt GM, Ryman BE. Liposomal entrapped second antibody improves tumour imaging with radiolabelled (first) antitumor antibody. Lancet. 1982;ii:739. - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources