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. 2015 Oct 22;10(10):e0140549.
doi: 10.1371/journal.pone.0140549. eCollection 2015.

Association Study between the FTCDNL1 (FONG) and Susceptibility to Osteoporosis

Hsing-Fang Lu  1 , Kuo-Sheng Hung  2 , Yu-Wen Hsu  3 , Yu-Ting Tai  4 , Lin-Shan Huang  3 , Yu-Jia Wang  3 , Henry Sung-Ching Wong  5 , Yi-Hsiang Hsu  6 , Wei-Chiao Chang  7
Affiliations

Association Study between the FTCDNL1 (FONG) and Susceptibility to Osteoporosis

Hsing-Fang Lu et al. PLoS One. .

Abstract

Osteoporosis is a systemic skeletal disease characterized by a decreased bone mineral density that results in an increased risk of fragility fractures. Previous studies indicated that genetic factors are involved in the pathogenesis of osteoporosis. Polymorphisms of the FONG (FTCDNL1) gene (rs7605378) were reported to be associated with the risk of osteoporosis in a Japanese population. To assess whether polymorphisms of the FTCDNL1 gene contribute to the susceptibility and severity of osteoporosis in a Taiwanese population, 326 osteoporosis patients and 595 controls of a Taiwanese population were included in this study. Our results indicated that rs10203122 was significantly associated with osteoporosis susceptibility among female. Our findings provide evidence that rs10203122 in FTCDNL1 is associated with a susceptibility to osteoporosis.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Graphical overview of the genotyped human FTCDNL1 gene.
Fig 2
Fig 2. FTCDNL1 gene linkage disequilibrium and haplotype block structure in osteoporosis.
The number on the cell is the D’ (D’ x 100).
See this image and copyright information in PMC

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