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. 1989 Jan;75(1):106-12.

Cellular infiltration in induced rat thyroiditis: phenotypic analysis and relationship to genetic restriction

H J De Assis-Paiva  1 , D C Rayner, I M Roitt, A Cooke
Affiliations

Cellular infiltration in induced rat thyroiditis: phenotypic analysis and relationship to genetic restriction

H J De Assis-Paiva et al. Clin Exp Immunol. 1989 Jan.

Abstract

We have investigated the responsiveness to thyroglobulin (Tg) plus complete Freund's adjuvant (CFA) and B. pertussis in a variety of inbred and MHC congenic strains of rats in terms of both Tg-autoantibody titres and histological thyroiditis index. Severity of thyroiditis was strongly Tg-dependent and closely related to the RT.1-MHC haplotype. Phenotypic examination of the inflammatory thyroid infiltrate using single and double indirect immunofluorescence techniques revealed a high proportion of macrophages and T lymphocytes, mainly of the cytotoxic/suppressor subset, in the high responder strains. Thyroid epithelial class II MHC expression although not prominent was strain-restricted and related to the amount of Ia+ leukocyte infiltrate.

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