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Comment
. 2015 Oct 23;350(6259):376-7.
doi: 10.1126/science.aad3981.

STRUCTURAL BIOLOGY. Assembling the wheel of death

Zhonghua Liu  1 , Tsan Sam Xiao  2
Affiliations
Comment

STRUCTURAL BIOLOGY. Assembling the wheel of death

Zhonghua Liu et al. Science. .
No abstract available

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Figures

Figure 1
Figure 1. Getting ready for defense
Reconstruction of the assembling inflammasome complex reported by Hu et al. and Zhang et al. Red, NAIP2 protein; cyan, NLRC4 proteins.
Figure 2
Figure 2. Add just one NAIP
Bacterial infections activate the NAIP2-NLRC4 inflammasomes, which promote the activation of caspase-1 and maturation of proinflammatory cytokines interleukin-1β (IL-1β) and IL-18, as well as pyroptotic cell death. Hu et al. and Zhang et al. show that a single ligand-bound NAIP2 protein triggers the progressive assembly of the NAIP2-NLRC4 inflammasomes through large conformational changes in NLRC4 and perhaps NAIP2. Similar mechanisms could govern the assembly of the NLRP3 inflammasome. (Bottom) Cryo-EM images of the assembling inflammasome.
See this image and copyright information in PMC

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References

    1. Schroder K, Tschopp J. Cell. 2010;140:821. - PubMed
    1. Guo H, Callaway JB, Ting JPY. Nat Med. 2015;21:677. - PMC - PubMed
    1. Zhang L, et al. Science. 2015;350:404. - PMC - PubMed
    1. Hu Z, et al. Science. 2015;350:399. - PubMed
    1. Kofoed EM, Vance RE. Nature. 2011;477:592. - PMC - PubMed

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