The Dawning of a New Day in CKD Anemia Care?
- PMID: 26494832
- PMCID: PMC4814199
- DOI: 10.1681/ASN.2015091009
The Dawning of a New Day in CKD Anemia Care?
Keywords: VEGF; anemia; hypoxia.
Comment on
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Four-Week Studies of Oral Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitor GSK1278863 for Treatment of Anemia.J Am Soc Nephrol. 2016 Apr;27(4):1234-44. doi: 10.1681/ASN.2014111139. Epub 2015 Oct 22. J Am Soc Nephrol. 2016. PMID: 26494831 Free PMC article. Clinical Trial.
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Roxadustat (FG-4592): Correction of Anemia in Incident Dialysis Patients.J Am Soc Nephrol. 2016 Apr;27(4):1225-33. doi: 10.1681/ASN.2015030241. Epub 2015 Oct 22. J Am Soc Nephrol. 2016. PMID: 26494833 Free PMC article. Clinical Trial.
References
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- Kaelin WG, Jr., Ratcliffe PJ: Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway. Mol Cell 30: 393–402, 2008 - PubMed
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- Semenza GL: Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology. Annu Rev Pathol 9: 47–71, 2014 - PubMed
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- Wong BW, Kuchnio A, Bruning U, Carmeliet P: Emerging novel functions of the oxygen-sensing prolyl hydroxylase domain enzymes. Trends Biochem Sci 38: 3–11, 2013 - PubMed
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