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Review
. 2015:2015:315957.
doi: 10.1155/2015/315957. Epub 2015 Oct 1.

Comparative Immune Response in Children and Adults with H. pylori Infection

Alireza Razavi  1 , Nader Bagheri  1 , Fatemeh Azadegan-Dehkordi  2 , Mahsa Shirzad  3 , Ghorbanali Rahimian  4 , Mahmoud Rafieian-Kopaei  5 , Hedaytollah Shirzad  2
Affiliations
Review

Comparative Immune Response in Children and Adults with H. pylori Infection

Alireza Razavi et al. J Immunol Res. 2015.

Abstract

Helicobacter pylori (H. pylori) infection is generally acquired during early childhood; therefore, the immune response which usually takes place at this age may influence or even determine susceptibility to the infection contributing to the clinical outcomes in adulthood. Several cytokines including IL-6, IL-10, and TGF-β1 as well as Foxp3(+) cell numbers have been shown to be higher; however, some other cytokines consisting of IL-1β, IL-17A, and IL-23 are lower in infected children than in infected adults. Immune response to H. pylori infection in children is predominant Treg instead of Th17 cell response. These results indicate that immune system responses probably play a role in persistent H. pylori infection. Childhood H. pylori infection is also associated with significantly lower levels of inflammation and ulceration compared with adults. This review, therefore, aimed to provide critical findings of the available literature about comparative immune system in children and adults with H. pylori infection.

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Figures

Figure 1
Figure 1
Diagram of how the Treg cell response may influence inflammation, bacterial colonization density, and occurrence of H. pylori-mediated disease.
See this image and copyright information in PMC

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