Role of CSL-dependent and independent Notch signaling pathways in cell apoptosis
- PMID: 26496776
- DOI: 10.1007/s10495-015-1188-z
Role of CSL-dependent and independent Notch signaling pathways in cell apoptosis
Abstract
Apoptosis is a normally biological phenomenon in various organisms, involving complexly molecular mechanisms with a series of signaling processes. Notch signaling is found evolutionarily conserved in many species, playing a critical role in embryonic development, normal tissue homeostasis, angiogenesis and immunoregulation. The focus of this review is on currently novel advances about roles of CSL-dependent and independent Notch signaling pathways in cell apoptosis. The CSL can bind Notch intracellular domain (NIC) to act as a switch in mediating transcriptional activation or inactivation of the Notch signaling pathway downstream genes in the nucleus. It shows that CSL-dependent signaling regulates the cell apoptosis through Hes-1-PTEN-AKT-mTOR signaling, but rather the CSL-independent signaling mediates the cell apoptosis possibly via NIC-mTORC2-AKT-mTOR signaling, providing a new insight into apoptotic mechanisms.
Keywords: Apoptosis; CSL-dependent Notch; CSL-independent Notch; Cell; mTORC.
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