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Review
. 2015 Dec;10(4):522-7.
doi: 10.1007/s11481-015-9640-y. Epub 2015 Oct 26.

Adaptive Immunity in Neurodegenerative and Neuropsychological Disorders

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Review

Adaptive Immunity in Neurodegenerative and Neuropsychological Disorders

R Lee Mosley. J Neuroimmune Pharmacol. 2015 Dec.

Abstract

Neurodegenerative and neuropsychological disorders are becoming a greater proportion of the global disease burden; however the pathogenic mechanisms by which these disorders originate and contribute to disease progression are not well-described. Increasing evidence supports neuroinflammation as a common underlying component associated with the neuropathological processes that effect disease progression. This collection of articles explores the role of adaptive immunity in autoimmunity, neurodegeneration, neurotrauma, and psychological disorders. The section emphasizes the interactions of T cells with innate cellular responses within the CNS and the effects on neurological functions. One recurrent theme is that modified and aggregated self-proteins upregulate innate-mediated inflammation and provide a permissive environment for polarization of T cells to proinflammatory effector cells. Moreover, infiltration and reactivation of those T effector cells exacerbate neuroinflammation and oxidative stress to greater neurotoxic levels. Another recurrent theme in these disorders promotes diminished regulatory functions that reduce control over activated T effector cells and microglia, and ultimately augment proinflammatory conditions. Augmentation of regulatory control is discussed as therapeutic strategies to attenuate neuroinflammation, mitigate neurodegeneration or neuronal dysfunction, and lessen disease progression.

Keywords: Adaptive immunity; Innate immunity; Neurodegeneration; Neuropsychological disorders.

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References

    1. J Neuroimmune Pharmacol. 2015 Dec;10(4):610-9 - PubMed
    1. Neurology. 2014 Jul 22;83(4):349-51 - PubMed
    1. J Steroid Biochem Mol Biol. 2016 Jun;160:127-33 - PubMed
    1. J Neuroimmune Pharmacol. 2015 Dec;10 (4):576-86 - PubMed
    1. J Neuroimmune Pharmacol. 2015 Dec;10 (4):645-50 - PubMed

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