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. 2015 Dec;36(12):799-801.
doi: 10.1016/j.tips.2015.09.006. Epub 2015 Oct 21.

PML: The Dark Side of Immunotherapy in Multiple Sclerosis

Clemens Warnke  1 , Tomas Olsson  2 , Hans-Peter Hartung  3
Affiliations

PML: The Dark Side of Immunotherapy in Multiple Sclerosis

Clemens Warnke et al. Trends Pharmacol Sci. 2015 Dec.

Abstract

Progressive multifocal leukoencephalopathy (PML) is a threat to patients with multiple sclerosis (MS) who undergo treatment with drugs that interfere with normal immune physiology. Here, we summarize PML incidence in MS, risk factors, surveillance strategies, and case definitions to inform neurologists and other clinicians treating patients with immune-mediated diseases.

Keywords: JC virus; PML; natalizumab; risk.

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